INT118824

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1, Nos1) aging (Nos1) mitochondrion organization (OPA1)
enzyme binding (Nos1) GTPase activity (OPA1) cytoplasm (Nos1)
Anatomy Link Frequency
nucleus 4
OPA1 (Homo sapiens)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 94.82 High High
nMDA receptor 2 94.04 High High
Sumatriptan 2 93.68 High High
agonist 1 93.20 High High
Neuronal nitric oxide synthase 1 87.08 High High
Migraine 1 80.28 Quite High
headache 2 72.96 Quite High
aspirin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 1 94.82 High High
Headache 3 80.28 Quite High
Epilepsy 1 65.36 Quite High
Cluster Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since NMDA receptors play a crucial role in trigeminal pain processing, the aim of our experiments was to compare the effects of L-kynurenine (L-KYN) combined with probenecid (PROB) or with 2-(2-N,N-dimethylaminoethylamine-1-carbonyl)-1H-quinolin-4-one hydrochloride alone, a newly synthetized KYNA derivative, on the NTG-induced nNOS expression in the rat TNC.
NTG Positive_regulation (induced) of Gene_expression (expression) of nNOS in TNC associated with pain and nmda receptor
1) Confidence 0.03 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.24 Pain Relevance 0.32
By contrast, pretreatment with lysine acetylsalicylate (50 mg/kg i.m.) attenuates the NTG-induced nNOS expression in the superficial laminae of trigeminal nucleus caudalis.
NTG Positive_regulation (induced) of Gene_expression (expression) of nNOS in nucleus
2) Confidence 0.02 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15154853 Disease Relevance 0 Pain Relevance 0.33

General Comments

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