INT118827

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP2A) nuclear chromosome (TOP2A) aging (TOP2A)
chromosome segregation (TOP2A) enzyme binding (TOP2A) DNA binding (TOP2A)
TOP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 1 30.88 Quite Low
headache 2 29.36 Quite Low
Paracetamol 2 9.20 Low Low
Analgesic 1 5.84 Low Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
eye pain 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 4 99.16 Very High Very High Very High
Bacterial Respiratory Disease 12 97.28 Very High Very High Very High
Conjunctivitis 59 91.32 High High
Poisoning 9 91.04 High High
Leukemia 18 84.60 Quite High
Colon Cancer 1 77.20 Quite High
Mrsa Infection 13 75.36 Quite High
Pneumonia 2 69.04 Quite High
Eye Infections 10 68.96 Quite High
Bronchitis 1 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These latter compounds, which target the prokaryotic type II topoisomerases DNA gyrase and topoisomerase IV, represent the most active and broad-spectrum antibacterials currently in clinical use (127–129).
Regulation (target) of gyrase associated with bacterial respiratory disease
1) Confidence 0.04 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.49 Pain Relevance 0
Gemifloxacin has been shown to target both DNA gyrase (preferred target) and topoisomerase IV (secondary target) - enzymes critical for DNA replication and organism survival - against clinical isolates of S. pneumoniae.
Regulation (target) of DNA gyrase
2) Confidence 0.03 Published 2004 Journal Expert Opin Pharmacother Section Abstract Doc Link 15155113 Disease Relevance 0.36 Pain Relevance 0
DNA gyrase, a topoisomerase found in all types of bacteria, is the primary target for gatifloxacin and moxifloxacin in most Gram-negative bacteria such as Escherichia coli, and, to a much lesser extent, in the Gram-positive species S. pneumoniae.
Regulation (target) of DNA gyrase
3) Confidence 0.02 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861926 Disease Relevance 0.32 Pain Relevance 0
Like other fluoroquinolones (FQs), besifloxacin targets DNA gyrase and topoisomerase IV, bacterial enzymes required for DNA replication.
Regulation (targets) of DNA gyrase
4) Confidence 0.01 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.58 Pain Relevance 0

General Comments

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