INT118833

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.14
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
macrophages 2
skeletal muscle 2
fibroblasts 2
Epithelium 2
keratinocytes 2
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 85 99.84 Very High Very High Very High
ischemia 21 99.32 Very High Very High Very High
methotrexate 50 96.72 Very High Very High Very High
Inflammatory response 10 94.48 High High
Inflammation 120 90.76 High High
tolerance 1 88.44 High High
rheumatoid arthritis 4 87.44 High High
Pain 4 87.32 High High
Angina 9 87.00 High High
psoriasis 2 85.44 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 79 99.84 Very High Very High Very High
Injury 56 99.32 Very High Very High Very High
Cv Unclassified Under Development 19 99.32 Very High Very High Very High
Hypoxia 12 99.10 Very High Very High Very High
Blindness 2 97.56 Very High Very High Very High
Retinal Neovascularization 2 96.80 Very High Very High Very High
Disease 117 94.40 High High
Diabetic Retinopathy 2 94.32 High High
INFLAMMATION 132 94.08 High High
Arterial Occlusive Diseases 1 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is reported that low concentration of oxygen free radicals in the wound site can promote angiogenesis by inducing VEGFA expression in keratinocytes [30] and macrophages [31] as well as stimulate collagen production [32].
Positive_regulation (inducing) of Gene_expression (expression) of VEGFA in keratinocytes associated with injury
1) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.71 Pain Relevance 0.04
In conditions of low oxygen tension, the cellular transcription factor HIF-1 (Hypoxia Inducible Factor–1) is post-translationally stabilized and activates the expression of a vast series of genes, among which the vascular endothelial growth factor (VEGF) and its receptors, which are required for all phases of angiogenesis (Liu et al 1995).
Positive_regulation (stabilized) of Gene_expression (expression) of vascular endothelial growth factor associated with hypoxia
2) Confidence 0.49 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.44 Pain Relevance 0.04
In conditions of low oxygen tension, the cellular transcription factor HIF-1 (Hypoxia Inducible Factor–1) is post-translationally stabilized and activates the expression of a vast series of genes, among which the vascular endothelial growth factor (VEGF) and its receptors, which are required for all phases of angiogenesis (Liu et al 1995).
Positive_regulation (required) of Gene_expression (expression) of vascular endothelial growth factor associated with hypoxia
3) Confidence 0.49 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.43 Pain Relevance 0.04
promote VEGF-A production by RA synovial fibroblasts.
Positive_regulation (promote) of Gene_expression (production) of VEGF in fibroblasts associated with arthritis
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.84 Pain Relevance 0.35
Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vascular endothelial growth factor in skeletal muscle
5) Confidence 0.40 Published 2004 Journal Circ. Res. Section Title Doc Link 15155530 Disease Relevance 0.34 Pain Relevance 0.21
The levels of VEGF 120 and 164 were increased only modestly with the addition of FOH.
Positive_regulation (increased) of Gene_expression (levels) of VEGF 120
6) Confidence 0.39 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.05 Pain Relevance 0
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Positive_regulation (measure) of Gene_expression (expression) of vascular endothelial growth factor
7) Confidence 0.28 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
Local tissue ischemia, due to endothelial dysfunction, increases the production of proangiogenic substances such as vascular endothelial growth factor (VEGF), angiogenin, VEGF receptor-2 (KDR), paralleled by decrease of the inhibitors of angiogenesis such as Pigment Epithelium Derived Factor (PEDF) result in retinal neovascularization as well as microangiopathy [5,6].
Positive_regulation (increases) of Gene_expression (production) of vascular endothelial growth factor in Epithelium associated with ischemia and retinal neovascularization
8) Confidence 0.26 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.77 Pain Relevance 0.21
Moreover, in previous studies, activation of both A2A and A2B receptors on either endothelial cells or macrophages has been reported to enhance the expression of vascular endothelial growth factor and to promote angiogenesis [21,49-51].
Positive_regulation (enhance) of Gene_expression (expression) of vascular endothelial growth factor in macrophages
9) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.67 Pain Relevance 0.57
In hypoxic conditions or in the absence of VHL, HIF-1a accumulates, stimulating the production of growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor a (TGF?)
Positive_regulation (as) of Gene_expression (production) of vascular endothelial growth factor associated with hypoxia
10) Confidence 0.21 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 1.37 Pain Relevance 0.12
In hypoxic conditions or in the absence of VHL, HIF-1a accumulates, stimulating the production of growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor a (TGF?)
Positive_regulation (stimulating) of Gene_expression (production) of vascular endothelial growth factor associated with hypoxia
11) Confidence 0.21 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 1.38 Pain Relevance 0.12

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