INT118835

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 11.20
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
fibroblasts 3
mast cell 2
endothelial cells 1
Th17 cells 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 7 99.98 Very High Very High Very High
Arthritis 573 99.36 Very High Very High Very High
agonist 23 98.90 Very High Very High Very High
Inflammation 214 98.16 Very High Very High Very High
cytokine 136 97.32 Very High Very High Very High
Inflammatory response 14 94.80 High High
mu opioid receptor 8 92.44 High High
Pain 13 89.28 High High
Angina 2 84.64 Quite High
interstitial cystitis 2 83.44 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 39 99.60 Very High Very High Very High
Rheumatoid Arthritis 577 99.36 Very High Very High Very High
Renal Insufficiency 1 99.36 Very High Very High Very High
Stress 31 99.20 Very High Very High Very High
Pressure And Volume Under Development 16 98.84 Very High Very High Very High
Hypoxia 10 98.70 Very High Very High Very High
INFLAMMATION 256 98.16 Very High Very High Very High
Apoptosis 92 97.72 Very High Very High Very High
Arterial Occlusive Diseases 1 97.44 Very High Very High Very High
Cancer 171 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of VEGF 120 and 164 were increased only modestly with the addition of FOH.
Positive_regulation (increased) of VEGF 120
1) Confidence 0.59 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0.05 Pain Relevance 0
In addition to VEGF administration, stimulation of VEGFRs, especially R2, such as during gene delivery, would be an alternative new therapeutic strategy for AHF in the future.


Positive_regulation (stimulation) of VEGF associated with acute liver failure
2) Confidence 0.49 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.43 Pain Relevance 0
did not induce VEGF-A or IL-6 secretion, and in fact reduced VEGF-A levels and IL-6 in 4 out of 6 fibroblast lines.
Neg (not) Positive_regulation (induce) of VEGF in fibroblast
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.42 Pain Relevance 0.29
Th17 cells in synovial fluid are associated with increased VEGF-A production
Positive_regulation (increased) of VEGF in Th17 cells
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.52 Pain Relevance 0.15
Similar increases in VEGF-A production were seen upon addition of rTNF?.
Positive_regulation (increases) of VEGF
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.43 Pain Relevance 0.30
promote VEGF-A production by RA synovial fibroblasts.
Positive_regulation (promote) of VEGF in fibroblasts associated with arthritis
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.84 Pain Relevance 0.35
did not induce VEGF-A secretion by RA synovial fibroblasts, which is in agreement with the lack of correlation between local Th1 cell frequency and PDUS signal.
Neg (not) Positive_regulation (induce) of VEGF in fibroblasts associated with arthritis
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.62 Pain Relevance 0.30
Acute stress and intravesical corticotropin-releasing hormone induces mast cell dependent vascular endothelial growth factor release from mouse bladder explants.
Positive_regulation (dependent) of vascular endothelial growth factor in mast cell associated with stress
8) Confidence 0.47 Published 2006 Journal J. Urol. Section Title Doc Link 16890727 Disease Relevance 0.43 Pain Relevance 0.21
CONCLUSIONS: Intravesical corticotropin-releasing hormone and acute restraint stress induced mast cell dependent vascular endothelial growth factor release from bladder explants.
Positive_regulation (dependent) of vascular endothelial growth factor in mast cell
9) Confidence 0.47 Published 2006 Journal J. Urol. Section Body Doc Link 16890727 Disease Relevance 0 Pain Relevance 0
In all three lines tested, a clear increase in VEGF-A as well as IL-6 was observed (Fig. 5E), indicating that the potentially antagonistic effect of rIFN?
Spec (clear) Positive_regulation (increase) of VEGF
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.55 Pain Relevance 0.34
In our patients, the angiogenic factor VEGF-A was significantly elevated in SF relative to paired serum (Fig. 5A, n?
Positive_regulation (elevated) of VEGF
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.51 Pain Relevance 0.15
In contrast to the results seen for the low alendronate dose, only the addition of FOH modestly restored VEGF 188 levels; neither FOH nor GGOH restored the 120 or 164 isoform levels.
Positive_regulation (restored) of VEGF 188
12) Confidence 0.39 Published 2009 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
Morphine stimulates vascular endothelial growth factor-like signaling in mouse retinal endothelial cells.
Positive_regulation (stimulates) of endothelial growth factor-like in endothelial cells associated with morphine
13) Confidence 0.36 Published 2006 Journal Current neurovascular research Section Title Doc Link 16918381 Disease Relevance 0 Pain Relevance 0.82
Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease.
Positive_regulation (using) of vascular endothelial growth factor associated with arterial occlusive diseases
14) Confidence 0.29 Published 2004 Journal Circ. Res. Section Abstract Doc Link 15155530 Disease Relevance 0.32 Pain Relevance 0.20
However, angiogenesis and vascular endothelial growth factor (VEGF) appeared to be increased by CGP42112A treatment in vivo.
Positive_regulation (increased) of vascular endothelial growth factor
15) Confidence 0.17 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.47 Pain Relevance 0.04
The level of vascular endothelial growth factor is increased in the patients who develop fluid retention with TZD therapy and this may lead to peripheral edema through increased vascular permeability [104].
Positive_regulation (increased) of vascular endothelial growth factor associated with pressure and volume under development and edema
16) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.38 Pain Relevance 0.06
Moreover, the hypoxia-inducible EDN1 promotes angiogenesis, reducing the possible effects of hypoxia-related oxidative stress [101,102], amongst other mechanisms by activation of the vascular endothelial growth factor.
Positive_regulation (activation) of vascular endothelial growth factor associated with stress and hypoxia
17) Confidence 0.10 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.49 Pain Relevance 0.31
agonists LY-171883 and WY-14,643 inhibit cyclo-oxygenase-2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1 [21].
Positive_regulation (activation) of vascular endothelial growth factor associated with colon cancer and agonist
18) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.20 Pain Relevance 0.12
As functional effects of TLR2 activation in RASFs, induction of vascular endothelial growth factor (VEGF) and IL-8 production were demonstrated after stimulation with bacterial peptidoglycan (a known ligand of TLR2) [5].
Positive_regulation (induction) of vascular endothelial growth factor
19) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.56 Pain Relevance 0.27

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