INT118837

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Context Info
Confidence 0.74
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.72
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mb)
Anatomy Link Frequency
muscle 2
B cells 1
skeletal muscle 1
hearts 1
Mb (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 89.64 High High
Angina 3 89.32 High High
ischemia 3 76.52 Quite High
Kinase C 18 50.00 Quite Low
Inflammation 30 47.24 Quite Low
adenocard 1 35.92 Quite Low
agonist 13 22.72 Low Low
Catechol-O-methyltransferase 27 5.00 Very Low Very Low Very Low
Dopamine 15 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amputation 3 99.60 Very High Very High Very High
Immunization 29 97.56 Very High Very High Very High
Stress 11 97.36 Very High Very High Very High
Sprains And Strains 60 95.48 Very High Very High Very High
Arterial Occlusive Diseases 3 94.44 High High
Hypoxia 22 92.32 High High
Fatigue 26 89.84 High High
Pain 7 89.64 High High
Cv General 3 Under Development 3 89.32 High High
Pulmonary Disease 98 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased myoglobin expression in VEGF-treated muscle implies an improved muscle oxygenation, which may, at least partly, explain observed clinical improvements in VEGF-treated patients, in the absence of improved vascularization.
Gene_expression (expression) of myoglobin in muscle
1) Confidence 0.74 Published 2004 Journal Circ. Res. Section Abstract Doc Link 15155530 Disease Relevance 0.15 Pain Relevance 0.03
Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo.
Gene_expression (expression) of myoglobin in skeletal muscle
2) Confidence 0.74 Published 2004 Journal Circ. Res. Section Title Doc Link 15155530 Disease Relevance 0.40 Pain Relevance 0.22
Furthermore, in ischemic muscle of 15 limb amputation patients, VEGF and myoglobin were coexpressed.
Gene_expression (coexpressed) of myoglobin in muscle associated with amputation
3) Confidence 0.74 Published 2004 Journal Circ. Res. Section Abstract Doc Link 15155530 Disease Relevance 0.35 Pain Relevance 0.16
With our technique the myoglobin spectrum is invariably consistent with full oxygenation and any (rare) hearts that do not show this pattern are discarded.
Gene_expression (spectrum) of myoglobin in hearts
4) Confidence 0.39 Published 2001 Journal BMC Physiol Section Body Doc Link PMC55339 Disease Relevance 0 Pain Relevance 0
It is possible that hemoglobin and myoglobin, absent in the in vitro situation, scavenge nitric oxygen (NO) and ROS, so that the detrimental effects of these substances are attenuated, at least for a limited period (Ordway and Garry 2004).
Neg (absent) Gene_expression (absent) of myoglobin
5) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.08 Pain Relevance 0
We found no SNPs, indels, or haplotypes that segregate with the pattern of expression for a ±2 Mb interval surrounding Comt.
Gene_expression (expression) of Mb
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.43 Pain Relevance 0
(Ighb) B cells also produced an NP-specific IgMb antibody response (Fig. 5 C).
Gene_expression (produced) of IgMb in B cells
7) Confidence 0.01 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.31 Pain Relevance 0

General Comments

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