INT118859

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.38
Pain Relevance 1.03

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signal transducer activity (GNA14, STAT3) signal transduction (GNA14, STAT3) plasma membrane (GNA14, STAT3)
nucleoplasm (STAT3) DNA binding (STAT3) GTPase activity (GNA14)
GNA14 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Kinase C 12 99.00 Very High Very High Very High
Enkephalin 4 86.08 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 4 89.28 High High
Leukemia 4 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various intermediates along the extracellular signal-regulated kinase signaling cascade were apparently required for Galpha14QL-induced STAT3 activation; they included Ras/Rac1, Raf-1, and mitogen-activated protein kinase kinase-1/2.
Galpha14QL Positive_regulation (activation) of STAT3
1) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.14 Pain Relevance 0.26
Requirements for PLCbeta, protein kinase C (PKC), and calmodulin-dependent kinase II (CaMKII) in Galpha14QL-induced STAT3 activation were demonstrated by their respective inhibitors as well as by coexpression of their dominant-negative mutants.
Galpha14QL Positive_regulation (activation) of STAT3 associated with kinase c
2) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.09 Pain Relevance 0.26
Inhibition of c-Src and Janus kinase 2 and 3 activities abolished STAT3 activation induced by Galpha14QL, but no physical association between Galpha14QL and c-Src could be detected by coimmunoprecipitation.
Galpha14QL Positive_regulation (activation) of STAT3
3) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.08 Pain Relevance 0.27
Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.
Galpha14 Positive_regulation (activation) of Signal transducer and activator of transcription 3 associated with opioid receptor
4) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Title Doc Link 15155836 Disease Relevance 0.08 Pain Relevance 0.24

General Comments

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