INT11887

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Context Info
Confidence 0.80
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 10.66
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
SK-OV-3 1
hepatocyte 1
mesothelial cells 1
epithelial cell 1
endometrium 1
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 13 99.28 Very High Very High Very High
endometriosis 1 97.08 Very High Very High Very High
Pain 12 85.12 High High
imagery 24 77.28 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1172 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 5 100.00 Very High Very High Very High
Ovarian Cancer 492 99.78 Very High Very High Very High
Dysmenorrhea 13 99.28 Very High Very High Very High
Endometriosis (extended) 2 97.08 Very High Very High Very High
Hemangiosarcoma 4 96.92 Very High Very High Very High
Immunotherapy Of Cancer 5 94.76 High High
Renal Failure 8 93.00 High High
Communicable Diseases 4 91.28 High High
Adenocarcinoma 2 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alternative forms of MUC1 and MUC16 lack the cytoplasmic tail portion of the protein and thus are secreted or shed into the tear film, as opposed to being anchored on epithelial cell membranes.
Localization (secreted) of MUC16 in epithelial cell
1) Confidence 0.80 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
To investigate the histogenic and cytogenic localization of CA 125 in patients with adenomyosis, sections from 8 adenomyosis cases were expressed with monoclonal anti-CA 125 antibodies.
Spec (investigate) Localization (localization) of CA 125 associated with dismenorea
2) Confidence 0.78 Published 1987 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 3472995 Disease Relevance 0.27 Pain Relevance 0.35
The human endometrium has been reported to release CA 125 in tissue culture, and elevated levels have been found in patients with endometriosis and adenomyosis.
Localization (release) of CA 125 in endometrium associated with endometriosis and dismenorea
3) Confidence 0.78 Published 1987 Journal Hum. Reprod. Section Abstract Doc Link 3474239 Disease Relevance 0.58 Pain Relevance 0.38
Both secreted (MUC2, MUC5AC, MUC5B, and MUC7) and membrane bound (MUC1, MUC4, and MUC16) mucin forms have been reported to be expressed by ocular surface epithelia [6,21,22].
Localization (secreted) of MUC16
4) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
The tumor cells were negative for CD34, CK20, alpha-fetoprotein, placental-like alkaline phosphatase, hepatocyte paraffin 1, polyclonal carcinoembryonic antigen, CD10, CA-125, prostate-specific antigen, and prostatic acid phosphatase.
Localization (like) of CA-125 in hepatocyte associated with cancer
5) Confidence 0.73 Published 2010 Journal Diagn. Cytopathol. Section Abstract Doc Link 19813270 Disease Relevance 0.95 Pain Relevance 0.08
We investigated the predictive value of CA125 normalization in addition to evaluating the absolute levels at baseline and 3 months after treatment.
Localization (normalization) of CA125
6) Confidence 0.72 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.34 Pain Relevance 0
However, the performance of the best two marker combination (MUC16 and WFDC2) was not significantly different from the best single marker (MUC16) as measured by pAUC (from specificity?
Localization (performance) of MUC16
7) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.22 Pain Relevance 0
Cell samples from overnight spent dialysis fluid were analyzed for viability, differential count, release of superoxide radicals, and cancer antigen 125 (CA 125).
Spec (analyzed) Localization (release) of CA 125 associated with cancer
8) Confidence 0.68 Published 1996 Journal Adv Perit Dial Section Abstract Doc Link 8865892 Disease Relevance 0.99 Pain Relevance 0.16
We conclude that significantly increased secretion of CA125 from heterotopic EC could be attributed to the increase in serum CA125 in patients with adenomyosis.
Localization (secretion) of CA125 associated with dismenorea
9) Confidence 0.62 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 1607752 Disease Relevance 0.18 Pain Relevance 0.18
Heterotopic EC in culture secreted nine times as much CA125 constitutively after reaching confluence as eutopic EC.
Localization (secreted) of CA125
10) Confidence 0.62 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 1607752 Disease Relevance 0.07 Pain Relevance 0.07
For example, consider a patient with normalized MUC16?
Localization (normalized) of MUC16
11) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0 Pain Relevance 0
In our study, the minimal tumor lesion sizes obtained by the sensitivity analysis under the assumption of tumor biomarker secretion by healthy cells (it is known that healthy mesothelial cells secrete CA125 [6]) ranged between several hundred mm3 and more than 106 mm3 for ovarian cancer.
Localization (secrete) of CA125 in mesothelial cells associated with cancer and ovarian cancer
12) Confidence 0.39 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2517618 Disease Relevance 1.32 Pain Relevance 0
The researchers then used their model to calculate the smallest tumor sizes that might be detectable with these biomarkers by feeding in existing data on CA125 and on PSA, including assay detection limits and the biomarker secretion rates of cancer cells growing in dishes.
Localization (secretion) of CA125 associated with cancer
13) Confidence 0.37 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2517618 Disease Relevance 1.41 Pain Relevance 0
When biomarker secretion by healthy cells is present (a more likely scenario), it was assumed that the secretion of CA125 by healthy cells accounts for up to 13.1 U/ml, and that tumor cells contribute the rest of the secretion up to the required cut-off level.
Localization (secretion) of CA125 associated with cancer
14) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2517618 Disease Relevance 1.45 Pain Relevance 0
The secretion rate of CA125 into cell culture medium by selected ovarian cancer cell lines (OVCAR-3, SK-OV-8, SK-OV-3 secreting 2–13 U/105 cells/20 h/ml medium) has been reported by Zeimet et al [6].
Localization (secretion) of CA125 in SK-OV-3 associated with ovarian cancer
15) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2517618 Disease Relevance 0.33 Pain Relevance 0
The mechanism regulating the production and/or secretion of mucin MUC16, which is recognized by the OC125 antibody, is as yet unknown, and it could potentially be altered by biochemical modulation of the tumor [133].
Localization (secretion) of MUC16 associated with cancer
16) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.98 Pain Relevance 0.04
A commonly followed biomarker in ovarian cancer trials is CA-125, a glycoprotein secreted by cancer cells.36 The relationship between the efficacy of PLD and CA-125 concentration changes has been extensively explored.
Localization (secreted) of CA-125 associated with cancer and ovarian cancer
17) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731020 Disease Relevance 0.72 Pain Relevance 0
Using a training set of 91 stage I data sets, representing 61 individual samples, and an equivalent number of controls, an 11-analyte profile, composed of CA-125, CA 19-9, EGF-R, C-reactive protein, myoglobin, apolipoprotein A1, apolipoprotein CIII, MIP-1?
Localization (apolipoprotein A1) of CA-125 associated with disorder of lipid metabolism
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2643010 Disease Relevance 0.84 Pain Relevance 0

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