INT118870

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 36
Total Number 38
Disease Relevance 26.18
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
T cells 3
intestinal cells 2
macrophages 2
epithelial cells 2
brain 1
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 647 100.00 Very High Very High Very High
Central nervous system 68 99.98 Very High Very High Very High
Inflammation 786 99.92 Very High Very High Very High
Inflammatory response 81 98.68 Very High Very High Very High
rheumatoid arthritis 235 96.88 Very High Very High Very High
chemokine 135 89.96 High High
agonist 213 88.64 High High
Spinal cord 19 86.56 High High
opioid receptor 2 83.28 Quite High
Osteoarthritis 96 82.16 Quite High
Disease Link Frequency Relevance Heat
Stress 80 100.00 Very High Very High Very High
Repression 35 100.00 Very High Very High Very High
Infection 110 99.98 Very High Very High Very High
INFLAMMATION 895 99.92 Very High Very High Very High
Rheumatoid Arthritis 370 99.84 Very High Very High Very High
Carcinoma 19 99.84 Very High Very High Very High
Asthma 1260 99.36 Very High Very High Very High
Myeloproliferative Disorder 45 99.16 Very High Very High Very High
Disease Progression 21 98.92 Very High Very High Very High
Hypoxia 49 98.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the constitutive activation of the JAK/STAT pathway in JAKV617F+MPN can result in subsequent epigenetic silencing of tumour suppressor genes [27, 28], suggesting that these changes result in further evolution of the disease.
Positive_regulation (activation) of STAT associated with myeloproliferative disorder, cancer and disease
1) Confidence 0.67 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.35 Pain Relevance 0.12
The

orchestrated interaction of APCs and T cells in the CNS leads to activation of Jak-Stat

Positive_regulation (leads) of Stat in T cells associated with central nervous system
2) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.00 Pain Relevance 0.58
The activated STAT1/2 complex then migrates to the cell nucleus, forming a complex with IFN-regulatory factor 9 (IRF-9) where interaction with cellular DNA leads to expression of IFN-stimulated genes (ISGs).
Positive_regulation (activated) of STAT1 in nucleus
3) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621394 Disease Relevance 0.52 Pain Relevance 0.09
FIV infection up-regulated inducible NO synthase (iNOS), STAT-1, and TNF-alpha mRNA levels in DRG cultures.
Positive_regulation (up-regulated) of STAT-1 in DRG associated with infection
4) Confidence 0.48 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.44 Pain Relevance 0.11
Increased STAT-1 and iNOS mRNA levels were also observed in DRGs from FIV-infected animals relative to mock-infected controls.
Positive_regulation (Increased) of STAT-1
5) Confidence 0.48 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.39 Pain Relevance 0.10
The present studies indicate that FIV infection of DRGs directly contributes to axonal and neuronal injury through a mechanism involving macrophage immune activation, which is mediated by STAT-1 and iNOS activation.
Positive_regulation (activation) of STAT-1 in neuronal associated with injury and infection
6) Confidence 0.48 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 0.75 Pain Relevance 0
was induced and their siRNA transfection resulted in attenuation of hypoxic/DHP-d activated stem cell growth and related signal protein activation, including MAPK, JAK/STAT, and AKT (Figure 3E).
Positive_regulation (activation) of STAT in stem cell associated with hypoxia
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.54 Pain Relevance 0
The results confirmed that the activation of the majority of genes by IFNgamma required STAT1.
Positive_regulation (required) of STAT1
8) Confidence 0.45 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.39 Pain Relevance 0
STAT1 is involved in cytokine signal transduction and is known to be activated by arsenic [19].
Positive_regulation (activated) of STAT1 associated with cytokine
9) Confidence 0.40 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.33 Pain Relevance 0.09
Moreover, it has been shown that the acetylation status of STAT1 (signal transducer and activator of transcription) [44], STAT3 [45], as well as NF-kappa B, is related to their degree of activation/deactivation, which affects the cytokine secretion profile [23].
Positive_regulation (related) of STAT1 associated with cytokine
10) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.62 Pain Relevance 0.09
response from patient to patient showed the highest variability among the cytokine responses, even though paired cultures from individual patients exhibited highly consistent levels of STAT1 activation by IFN?.
Positive_regulation (activation) of STAT1 associated with cytokine
11) Confidence 0.36 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.05
Similarly, immunolabeling studies of DRGs from FIV-infected animals showed that macrophages were the principal sources of STAT-1 and iNOS protein production.
Positive_regulation (sources) of STAT-1 in macrophages
12) Confidence 0.35 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.29 Pain Relevance 0.09
Moreover, it has been shown that the acetylation status of STAT1 (signal transducer and activator of transcription) [44], STAT3 [45], as well as NF-kappa B, is related to their degree of activation/deactivation, which affects the cytokine secretion profile [23].
Positive_regulation (related) of signal transducer and activator of transcription associated with cytokine
13) Confidence 0.35 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.61 Pain Relevance 0.09
and STAT1) were significantly activated in the PBMC of ERA patients compared with healthy individuals.
Positive_regulation (activated) of STAT1 associated with rheumatoid arthritis
14) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.40 Pain Relevance 0.35
To determine whether there is a general differential requirement for STAT1 in gene activation and gene repression in response to IFNgamma in intestinal cells, we performed genome-wide analysis of IFNgamma target genes in an IEC line in which STAT1 expression was silenced by small interfering RNA.
Spec (whether) Positive_regulation (response) of STAT1 in intestinal cells associated with repression
15) Confidence 0.32 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.49 Pain Relevance 0.06
Our results therefore demonstrate that in general gene activation by IFNgamma is more sensitive to STAT1 deficiency than gene repression, and suggest that IFNgamma activates and represses gene expression via distinct pathways that can be distinguished, at least in part, by their requirement for STAT1.
Positive_regulation (requirement) of STAT1 associated with repression
16) Confidence 0.32 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.33 Pain Relevance 0
To determine whether there is a general differential requirement for STAT1 in gene activation and gene repression in response to IFNgamma in intestinal cells, we performed genome-wide analysis of IFNgamma target genes in an IEC line in which STAT1 expression was silenced by small interfering RNA.
Spec (whether) Positive_regulation (requirement) of STAT1 in intestinal cells associated with repression
17) Confidence 0.32 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.48 Pain Relevance 0.06
Thus, unlike the activity of JAK, STAT1 is not required for the inhibition of COX-2 expression by IFNgamma.
Neg (not) Positive_regulation (required) of STAT1
18) Confidence 0.32 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.37 Pain Relevance 0.07
Recent studies reveal that several Galpha subunits are capable of activating signal transducer and activator of transcription (STAT) proteins.
Positive_regulation (activating) of signal transducer and activator of transcription
19) Confidence 0.29 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.07 Pain Relevance 0.22
induced transcription factor STAT1 and its binding to DNA response elements, thereby increasing the induction of ISGs and enhancing the inhibitory effect of IFN?
Positive_regulation (induced) of STAT1
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.37 Pain Relevance 0

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