INT118871

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 11.40
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
endothelial cell 1
neutrophils 1
JAK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 22 98.52 Very High Very High Very High
cytokine 92 97.76 Very High Very High Very High
Inflammation 157 93.40 High High
Osteoarthritis 189 90.68 High High
Enkephalin 1 80.16 Quite High
opioid receptor 2 78.68 Quite High
Kinase C inhibitor 3 78.48 Quite High
lidocaine 3 77.28 Quite High
headache 4 74.72 Quite High
Inflammatory response 7 73.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 345 99.26 Very High Very High Very High
Myelodysplastic Syndromes 137 99.12 Very High Very High Very High
Myeloproliferative Disorder 108 98.96 Very High Very High Very High
Chronic Myeloid Leukemia 13 98.96 Very High Very High Very High
Carcinoma 188 98.74 Very High Very High Very High
Myelofibrosis 75 98.68 Very High Very High Very High
INFLAMMATION 165 93.40 High High
Death 48 93.36 High High
Primary Sclerosing Cholangitis 31 92.48 High High
Adenocarcinoma 18 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discovery of JAK2V617F has led to the development of selective JAK2 inhibitors for the treatment of PV, ET and PMF (6, 16).
Negative_regulation (inhibitors) of JAK2 associated with myelodysplastic syndromes and myelofibrosis
1) Confidence 0.57 Published 2009 Journal Thromb J Section Body Doc Link PMC2652439 Disease Relevance 1.04 Pain Relevance 0.03
All patients were screened for defects in the Von Hippel-Lindau, HIF-1alpha, HIF-2alpha, PHD1-3, JAK2, and EPOR genes.
Negative_regulation (defects) of JAK2
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.60 Pain Relevance 0.13
Small molecular inhibitors of JAK2 signaling have already entered clinical trials.
Negative_regulation (inhibitors) of JAK2
3) Confidence 0.39 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.16 Pain Relevance 0.10
Synergistic induction of MPN cell apoptosis was also observed when LBH589 and a JAK2 inhibitor (TG101209) were combined [98].
Negative_regulation (inhibitor) of JAK2 associated with myeloproliferative disorder and apoptosis
4) Confidence 0.32 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.60 Pain Relevance 0
Preliminary studies indicate that HDACi when used in combination with TKIs or JAK2 inhibitors may overcome drug resistance and enhance the apoptotic effects on MPN cells.
Negative_regulation (inhibitors) of JAK2 associated with myeloproliferative disorder and apoptosis
5) Confidence 0.31 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.15 Pain Relevance 0
Enhanced apoptosis sensitivity of Mcl-1 expressing HCC cells to chemotherapy after inhibition of PI3K, but not after inhibition of Jak2, mTOR, MEK1, Src or Raf I kinase
Negative_regulation (inhibition) of Jak2 associated with carcinoma and apoptosis
6) Confidence 0.29 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0.06
The same applied for Jak2 inhibitors, although Jak2 has been shown to be ubiquitously activated in human HCC [38].
Negative_regulation (inhibitors) of Jak2 associated with carcinoma
7) Confidence 0.29 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.26 Pain Relevance 0
JAK2 inhibitor AG 490 (10 ?
Negative_regulation (inhibitor) of JAK2
8) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.20 Pain Relevance 0.17
M (JAK2 inhibitor), WHI-P154 10 ?
Negative_regulation (inhibitor) of JAK2
9) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.29 Pain Relevance 0.15
We studied the effects of inhibitors of JAK (JAK2 and JAK3), MAPK (Erk1/2, p38, JNK), PKC and NF-?
Negative_regulation (inhibitors) of JAK2 associated with kinase c
10) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.36 Pain Relevance 0.37
Suppressor of cytokine signaling 3 is the main isoform of that family of regulatory factors expressed in neutrophils and functions by inhibiting JAK2 kinase activity [54]–[57].
Negative_regulation (inhibiting) of JAK2 in neutrophils associated with cytokine
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.91 Pain Relevance 0.46
Further support is provided by the study of Zhu et al. showing that H-2g, a glucose analog of the blood group H antigen, mediates endothelial cell chemotaxis and induces expression of the proangiogenic factors VEGF and bFGF through pathways involving Jak2 and phosphoinositide-3 kinase that could be abolished by treatment with the respective inhibitors AG490 and LY294002 [102].
Negative_regulation (abolished) of Jak2 in endothelial cell
12) Confidence 0.14 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.79 Pain Relevance 0
Specific JAK-3 inhibitors, which have demonstrated immunosuppressive activity in small animal models, exhibit fewer of the hematological side effects seen with those agents that also inhibit JAK-2.

18.

Negative_regulation (inhibit) of JAK-2
13) Confidence 0.13 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.29 Pain Relevance 0.06
Inhibition of c-Src and Janus kinase 2 and 3 activities abolished STAT3 activation induced by Galpha14QL, but no physical association between Galpha14QL and c-Src could be detected by coimmunoprecipitation.
Negative_regulation (Inhibition) of Janus kinase 2
14) Confidence 0.13 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.08 Pain Relevance 0.28
There was a significant reduction in TLR4 mRNA expression following PAF stimulation in those cells pretreated with Tyrphostin AG490 (an indirect STAT3 inhibitor, via JAK2 inhibition), Bay 11–7082 (an inhibitor of NF?
Negative_regulation (inhibition) of JAK2
15) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.11 Pain Relevance 0.03
c.154 Cross-linking experiments have revealed that upon IRp60/CD300a activation, JAK2, p38, and extracellular signal-regulated kinase 1/2 phosphorylation are inhibited, probably from the recruitment of SHP-1 and not SHP-2.
Negative_regulation (inhibited) of JAK2
16) Confidence 0.07 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.65 Pain Relevance 0.34

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