INT118884

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.71
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF1) nucleoplasm (IRF1) nucleus (IRF1)
Anatomy Link Frequency
MAR 2
IRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Glutamate 10 99.84 Very High Very High Very High
member 8 4 99.36 Very High Very High Very High
metalloproteinase 4 46.88 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
positron emission tomography 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
Cancer 84 96.20 Very High Very High Very High
Neck Pain 2 92.88 High High
Reprotox - General 1 8 90.44 High High
Breast Cancer 80 89.68 High High
Malignant Neoplastic Disease 8 83.84 Quite High
Myalgia 4 57.48 Quite High
Leiomyosarcoma 118 50.00 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Smooth Muscle Tumor 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreases in jaw clench-related EMG activity were observed in MAL, MAR and SCM muscles only during glutamate-evoked MAR pain.
Gene_expression (pain) of MAR in MAR associated with pain and glutamate
1) Confidence 0.66 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.67 Pain Relevance 0.95
Decreases in jaw clench-related EMG activity were observed in MAL, MAR and SCM muscles only during glutamate-evoked MAR pain.
Gene_expression (muscles) of MAR in MAR associated with pain and glutamate
2) Confidence 0.58 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.67 Pain Relevance 0.95
Microarray analysis has elucidated that LMP2 expression dramatically influences the expression pattern of cell-cycle regulators, especially anti-oncogenic factor interferon regulatory factor 1 (IRF-1), which directly correlate to progressively worsen with the increasing stage and grade of the tumor (Fig. 3).
Gene_expression (expression) of IRF-1 associated with cancer
3) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.40 Pain Relevance 0
Microarray analysis has elucidated that LMP2 expression dramatically influences the expression pattern of cell-cycle regulators, especially anti-oncogenic factor interferon regulatory factor 1 (IRF-1), which directly correlate to progressively worsen with the increasing stage and grade of the tumor (Fig. 3).
Gene_expression (expression) of anti-oncogenic factor interferon regulatory factor 1 associated with cancer
4) Confidence 0.25 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.40 Pain Relevance 0
BAC = bacterial artificial chromosome; CGH = comparative genomic hybridization; CNA = copy number alteration; EGFR = epidermal growth factor receptor; FISH = fluorescence in situ hybridization; kb = kilobases; MAR = minimum altered region; Mb = megabases; SMRT = submegabase-resolution tiling set; SNP = single nucleotide polymorphism.


Gene_expression (megabases) of MAR
5) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.22 Pain Relevance 0
Only one gene resides within this MAR: that encoding transient receptor potential cation channel subfamily A, member 1 (TRAPA1).
Gene_expression (resides) of MAR associated with member 8
6) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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