INT118887

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 8.39
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu3) plasma membrane (Neu3) carbohydrate metabolic process (Neu3)
Anatomy Link Frequency
dendrites 1
motor neurons 1
neural 1
Neu3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 4 98.52 Very High Very High Very High
Inflammation 10 97.94 Very High Very High Very High
Central nervous system 33 96.92 Very High Very High Very High
gABA 88 95.64 Very High Very High Very High
Spinal cord 17 94.68 High High
antagonist 99 87.12 High High
agonist 90 86.52 High High
Gabapentin 11 84.44 Quite High
beta blocker 11 79.12 Quite High
Delta opioid receptors 2 75.84 Quite High
Disease Link Frequency Relevance Heat
Tremor 1276 99.76 Very High Very High Very High
INFLAMMATION 4 97.94 Very High Very High Very High
Movement Disorders 22 97.72 Very High Very High Very High
Neurological Disease 22 90.56 High High
Targeted Disruption 8 88.28 High High
Aging 22 75.52 Quite High
Inflammatory Pain 6 75.00 Quite High
Syndrome 11 63.08 Quite High
Dystonia 11 61.12 Quite High
Epilepsy 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in the membrane density of deltaOR was likely due to a recruitment of receptors from intracellular stores since no difference in the overall deltaOR immunolabeling density was evident between CFA-treated and untreated mice.
Positive_regulation (increase) of membrane
1) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.61 Pain Relevance 0.71
The CFA-induced inflammation produced a significantly higher ratio of plasma membrane to intracellular receptors, as well as a 75% increase in the membrane density of immunoreactive deltaOR, in dendrites of the ipsilateral dorsal horn as compared to untreated mice.
Positive_regulation (increase) of membrane in dendrites associated with inflammation and dorsal horn
2) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.63 Pain Relevance 0.63
In our model we increased the Ih to increase membrane excitability and produce oscillations.
Positive_regulation (increase) of membrane
3) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.05 Pain Relevance 0.12
These simulations support the hypothesis that increased membrane excitability in potentially unstable, reciprocally innervated circuits can produce oscillations that resemble ET.
Positive_regulation (increased) of membrane associated with tremor
4) Confidence 0.00 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2613385 Disease Relevance 0.52 Pain Relevance 0.11
If they are higher, Ih could be increased and thus lead to an increase in membrane excitability.


Positive_regulation (increase) of membrane
5) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.82 Pain Relevance 0.12
Therefore we hypothesize that increased membrane excitability in pre-motor neurons has a key role in pathogenesis of ET.
Positive_regulation (increased) of membrane in motor neurons associated with tremor
6) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 1.02 Pain Relevance 0.33
Increasing the membrane excitability in our lumped model
Positive_regulation (Increasing) of membrane
7) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0 Pain Relevance 0.16
We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET.
Positive_regulation (increased) of membrane associated with tremor
8) Confidence 0.00 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2613385 Disease Relevance 0.69 Pain Relevance 0
By increasing specific membrane conductances that are known to increase PIR and neural excitability, such as Ih and IT, we could simulate the range of frequencies of tremor recorded from ET patients.


Positive_regulation (increasing) of membrane in neural associated with tremor
9) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.99 Pain Relevance 0
In this study membrane excitability was increased by up-regulating Ih and IT.
Positive_regulation (increased) of membrane
10) Confidence 0.00 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2613385 Disease Relevance 0.34 Pain Relevance 0.10
How increased membrane excitability affects motor control?
Positive_regulation (increased) of membrane
11) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 1.08 Pain Relevance 0.11
Increases in membrane excitability could affect motor control in many ways.
Positive_regulation (Increases) of membrane
12) Confidence 0.00 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 1.05 Pain Relevance 0.12
In contrast, increasing other membrane conductances, while keeping Ih at a physiological value, did not simulate the tremor.
Positive_regulation (increasing) of membrane associated with tremor
13) Confidence 0.00 Published 2008 Journal J Transl Med Section Abstract Doc Link PMC2613385 Disease Relevance 0.60 Pain Relevance 0.12

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