INT118888

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 1.43
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neuronal 2
nerve 2
peripheral nerve 2
skin 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 130 100.00 Very High Very High Very High
Pain 24 100.00 Very High Very High Very High
nociceptor 19 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Nerve growth factor 100 99.48 Very High Very High Very High
Trigeminal ganglion neurons 1 99.32 Very High Very High Very High
dorsal root ganglion 60 97.74 Very High Very High Very High
Inflammation 25 89.32 High High
Dorsal horn 14 87.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 124 99.16 Very High Very High Very High
Hypersensitivity 13 90.32 High High
INFLAMMATION 25 89.32 High High
Nervous System Injury 2 84.84 Quite High
Nociception 23 72.32 Quite High
Targeted Disruption 1 71.20 Quite High
Paralysis 1 59.60 Quite High
Pain 17 6.64 Low Low
Injury 24 5.00 Very Low Very Low Very Low
Hyperalgesia 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies show that TRPV1 in DRG neuronal cell bodies and peripheral terminals are preserved, suggesting that sensory efferent functions such as TRPV1-mediated CGRP and SP release at the peripheral nerve terminals will not be affected.
Neg (not) Regulation (affected) of Localization (release) of TRPV1 in peripheral nerve associated with dorsal root ganglion
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.71 Pain Relevance 0.62
Our observation is also in line with the finding that S800 is crucially involved in PMA-mediated sensitization of TRPV1 via PKC-?
Regulation (involved) of Localization (sensitization) of TRPV1
2) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.16
Treatment of trigeminal ganglion neurons in vitro with NGF, GDNF or BDNF: effects on neuronal survival, neurochemical properties and TRPV1-mediated neuropeptide secretion

Background

Regulation (effects) of Localization (secretion) of TRPV1 in neuronal associated with ganglion cysts, neuropeptide and trigeminal ganglion neurons
3) Confidence 0.25 Published 2005 Journal BMC Neurosci Section Title Doc Link PMC548274 Disease Relevance 0.50 Pain Relevance 0.58
Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.
Regulation (Effects) of Localization (release) of TRPV1 in skin associated with qutenza and antagonist
4) Confidence 0.23 Published 2004 Journal Pain Section Title Doc Link 15157689 Disease Relevance 0.16 Pain Relevance 1.25
These data suggest that responses of SARs to ammonia in rats do not depend on release of mediators by nerve endings containing TRPV1 and are not secondary to bronchoconstriction.
Neg (not) Regulation (depend) of Localization (release) of TRPV1 in nerve
5) Confidence 0.23 Published 2007 Journal Auton Neurosci Section Abstract Doc Link 17169618 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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