INT118891

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga2) plasma membrane (Itga2) nucleus (Itga2)
Anatomy Link Frequency
spinal 1
Itga2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 98.56 Very High Very High Very High
projection neuron 1 91.08 High High
GABAergic 1 85.52 High High
Spinal cord 3 85.08 High High
Dorsal horn 2 84.32 Quite High
gABA 1 77.04 Quite High
Nicotine 1 75.00 Quite High
Analgesic 2 66.44 Quite High
Antinociceptive 1 60.96 Quite High
analgesia 1 39.44 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beside the most expressed subunits alpha4, beta2 and alpha7, the alpha2 subunit transcript was found in 19% of neurons, suggesting that agonists targeting alpha2* nAChRs may have specific actions at a spinal level without major supra-spinal effects.
Transcription (found) of alpha2 subunit in spinal associated with agonist
1) Confidence 0.03 Published 2004 Journal Pain Section Abstract Doc Link 15157692 Disease Relevance 0 Pain Relevance 0.54

General Comments

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