INT1189

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.10
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AMPD1) small molecule metabolic process (AMPD1)
Anatomy Link Frequency
pleural fluid 1
nerve 1
stem cell 1
AMPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 4 100.00 Very High Very High Very High
cytokine 2 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
agonist 1 93.32 High High
halothane 4 92.40 High High
palliative 1 87.92 High High
tetrodotoxin 1 81.48 Quite High
abdominal pain 1 79.64 Quite High
Arthritis 1 79.28 Quite High
alcohol 1 74.52 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Purine Or Pyrimidine Metabolism 5 100.00 Very High Very High Very High
Malignant Hyperthermia 3 99.80 Very High Very High Very High
Neuropathic Pain 3 99.28 Very High Very High Very High
Hepatic Porphyrias 2 97.84 Very High Very High Very High
Myalgia 3 97.20 Very High Very High Very High
Porphyria 5 97.08 Very High Very High Very High
Lymphatic System Cancer 10 95.76 Very High Very High Very High
Disease 3 95.24 Very High Very High Very High
Contracture 4 93.40 High High
Pleurisy 2 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three of 266 biopsied for other conditions were MADA-deficient.
Gene_expression (deficient) of MADA
1) Confidence 0.59 Published 1982 Journal Neurology Section Abstract Doc Link 7201581 Disease Relevance 0.41 Pain Relevance 0
Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: is there a relationship?
Gene_expression (deficiency) of Myoadenylate deaminase associated with malignant hyperthermia and disorder of purine or pyrimidine metabolism
2) Confidence 0.42 Published 1985 Journal Biochem Med Section Title Doc Link 4096721 Disease Relevance 0.51 Pain Relevance 0.15
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Gene_expression (deficiency) of deaminase associated with neuropathic pain and hepatic porphyrias
3) Confidence 0.15 Published 1996 Journal Nat. Genet. Section Title Doc Link 8563760 Disease Relevance 1.09 Pain Relevance 0.12
The third reaction, the AMP deaminase reaction, does not regenerate ATP.
Gene_expression (reaction) of deaminase
4) Confidence 0.09 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0.14 Pain Relevance 0
Evidence that ATP is the transmitter released from purinergic nerves includes: (1) synthesis and storage of ATP in nerves; (2) release of ATP from the nerves when they are stimulated; (3) exogenously applied ATP mimicking the action of nerve-released transmitter, both producing a specific increase in K+ conductance; (4) the presence of Mg-activated ATPase, 5'-nucleotidase and adenosine deaminase, enzymes which inactivate ATP; (5) drugs (including quinidine, some 2-substituted imidazolines, 2-2'pyridylisatogen and dipyridamole) which produce similar blocking or potentiating effects on the response to exogenously applied ATP and nerve stimulation.
Gene_expression (presence) of deaminase in nerve associated with adenocard
5) Confidence 0.07 Published 1975 Journal J. Exp. Zool. Section Abstract Doc Link 172588 Disease Relevance 0.06 Pain Relevance 0.13
The pleural fluid analysis showed a lymphocytic exudate with glucose level of 106 mg/dL, adenosine deaminase of 56 U/L, and negative cultures for pathogens; the oncotic cytology was negative and the pleural biopsy showed chronic non?
Gene_expression (adenosine) of deaminase in pleural fluid associated with adenocard
6) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020354 Disease Relevance 0.92 Pain Relevance 0.21
Other novel agents include the interleukin (IL)-2 fusion toxin (ONTAK), pentostatin (a potent adenosine deaminase inhibitor), histone deacetylase inhibitors such as depsipeptide, NF-kappaB inhibitors, cytokine receptor antagonists, immunomodulatory therapies and allogeneic stem cell therapy.
Gene_expression (antagonists) of deaminase in stem cell associated with adenocard, antagonist and cytokine
7) Confidence 0.00 Published 2003 Journal Leuk. Lymphoma Section Abstract Doc Link 15202526 Disease Relevance 0.97 Pain Relevance 0.28

General Comments

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