INT118905

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.55
Pain Relevance 12.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
neurons 2
posterior 2
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 289 100.00 Very High Very High Very High
Acupuncture 156 100.00 Very High Very High Very High
amygdala 60 100.00 Very High Very High Very High
Anterior cingulate cortex 10 100.00 Very High Very High Very High
Morphine 165 99.54 Very High Very High Very High
Thalamus 11 99.20 Very High Very High Very High
Pain 161 98.56 Very High Very High Very High
withdrawal 11 98.28 Very High Very High Very High
opiate 13 97.84 Very High Very High Very High
tolerance 26 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 306 100.00 Very High Very High Very High
Pain 170 98.56 Very High Very High Very High
INFLAMMATION 8 96.60 Very High Very High Very High
Anxiety Disorder 39 96.40 Very High Very High Very High
Stress 99 94.36 High High
Hyperalgesia 6 93.76 High High
Depression 2 93.52 High High
Inflammatory Pain 10 89.56 High High
Post-traumatic Stress Disorder 14 39.16 Quite Low
Cold Sores 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Distraction significantly increased the activation of the cingulo-frontal cortex including the orbitofrontal and perigenual anterior cingulate cortex (ACC), as well as the periaquaeductal gray (PAG) and the posterior thalamus.
Positive_regulation (increased) of Positive_regulation (activation) of PAG in posterior associated with urological neuroanatomy, thalamus and anterior cingulate cortex
1) Confidence 0.40 Published 2004 Journal Pain Section Abstract Doc Link 15157701 Disease Relevance 1.26 Pain Relevance 1.35
together, these data provide compelling support for a central role of the PAG
Positive_regulation (support) of Positive_regulation (role) of PAG associated with central grey
2) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.57 Pain Relevance 1.86
hindpaw caused extensive activation of PAG neurons as measured by Fos labeling.
Positive_regulation (caused) of Positive_regulation (activation) of PAG in neurons associated with central grey
3) Confidence 0.36 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.46 Pain Relevance 1.43
Liu et al. (21) also noticed a dramatically increased acupuncture-induced activation of the PAG in humans with both Li4 and a non-acupuncture point.
Positive_regulation (induced) of Positive_regulation (activation) of PAG associated with acupuncture and central grey
4) Confidence 0.17 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193550 Disease Relevance 0.74 Pain Relevance 1.91
It appeared PAG activation, while present as a consequence of non-acupuncture point stimulation, was substantially enhanced by stimulation of a true acupuncture point.
Positive_regulation (enhanced) of Positive_regulation (activation) of PAG associated with acupuncture and central grey
5) Confidence 0.17 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193550 Disease Relevance 0.73 Pain Relevance 1.89
Liu et al. (21) also noticed a dramatically increased acupuncture-induced activation of the PAG in humans with both Li4 and a non-acupuncture point.
Positive_regulation (increased) of Positive_regulation (activation) of PAG associated with acupuncture and central grey
6) Confidence 0.17 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193550 Disease Relevance 0.74 Pain Relevance 1.93
Moreover, morphine-withdrawn rats had an increase in the reactivity to the electrical stimulation of the dPAG and the IC.
Positive_regulation (increase) of Positive_regulation (stimulation) of dPAG associated with morphine
7) Confidence 0.16 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18577378 Disease Relevance 0.81 Pain Relevance 1.25
potentiation of the CeA-PAG pathway in the right hemisphere (Figure 4) analogous to that seen after
Positive_regulation (potentiation) of Positive_regulation (pathway) of PAG associated with central grey and amygdala
8) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.23 Pain Relevance 0.64

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