INT118906

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 17.95
Pain Relevance 11.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
joint 1
spinal 1
glial cell 1
paw 1
nerve 1
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 39 100.00 Very High Very High Very High
Eae 29 100.00 Very High Very High Very High
Dynorphin 7 99.92 Very High Very High Very High
ischemia 97 99.84 Very High Very High Very High
Perioperative pain 43 99.84 Very High Very High Very High
intrathecal 73 99.72 Very High Very High Very High
Endocannabinoid 50 99.62 Very High Very High Very High
Intracerebroventricular 1 99.46 Very High Very High Very High
Osteoarthritis 30 99.44 Very High Very High Very High
Hyperalgesia 64 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 105 100.00 Very High Very High Very High
Inflammatory Pain 23 100.00 Very High Very High Very High
Cv Unclassified Under Development 70 99.84 Very High Very High Very High
Post Operative Pain 45 99.84 Very High Very High Very High
Osteoarthritis 42 99.44 Very High Very High Very High
Arthritis 57 99.16 Very High Very High Very High
INFLAMMATION 327 99.00 Very High Very High Very High
Nociception 41 98.84 Very High Very High Very High
Nervous System Injury 89 98.56 Very High Very High Very High
Neuropathic Pain 131 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effect of a p38alpha MAPK inhibitor, SD-282, on mechanical allodynia, thermal hyperalgesia, and formalin-evoked nociception in streptozotocin-induced diabetic rats.
Spec (examined) Regulation (effect) of p38alpha associated with nociception, allodynia, diabetes mellitus and thermal hyperalgesia
1) Confidence 0.44 Published 2004 Journal Pain Section Abstract Doc Link 15157702 Disease Relevance 1.14 Pain Relevance 0.83
Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase.
Regulation (dependent) of p38 in spinal associated with dynorphin and intrathecal
2) Confidence 0.43 Published 2005 Journal Neuropeptides Section Title Doc Link 16176831 Disease Relevance 0.17 Pain Relevance 0.61
Although the effects of p38 inhibitor in OA models has not been previously reported the interleukin converting enzyme inhibitor pralnacasan was shown to reduce joint damage in a surgically induced model and a spontaneous model of OA in mice [40] demonstrating a benefit of cytokine inhibition.
Regulation (effects) of p38 in joint associated with osteoarthritis and cytokine
3) Confidence 0.41 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.36 Pain Relevance 0.90
METHODS: We assessed the influence of lidocaine on the levels of phospho-p38 MAPK, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and intracellular calcium triggered by extracellular adenosine triphosphate (ATP) in cultured rat microglia.
Regulation (influence) of p38 in microglia
4) Confidence 0.35 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20686009 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our results indicate that high glucose concentrations stimulate PSC activation via PKC-p38 MAP kinase pathway and suggest that high glucose may aggravate pancreatic fibrosis.


Regulation (stimulate) of p38
5) Confidence 0.34 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.12 Pain Relevance 0
Therefore, it seems likely that p-p38 is only involved in thermal hyperalgesia in inflammatory pain models, but is involved in both thermal and mechanical hyperalgesia in neuropathic pain models.
Regulation (involved) of p38 associated with hyperalgesia, eae and thermal hyperalgesia
6) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 1.79 Pain Relevance 1.46
Other molecules are known to influence p38 MAPK function in an arthritic state, including map kinase family members (such as ERK1/2) and NF?
Regulation (influence) of p38 associated with arthritis
7) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.30 Pain Relevance 0.53
Tight nerve ligation plus transection had no additional effect on P-p38 levels in DRG.
Neg (no) Regulation (ffect ) of p38 in nerve
8) Confidence 0.25 Published 2006 Journal J Pain Section Abstract Doc Link 16632323 Disease Relevance 0.51 Pain Relevance 1.10
Changes in connexin 26 and active p38 levels were determined by immunohistochemistry.
Regulation (Changes) of p38
9) Confidence 0.25 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0.07 Pain Relevance 0
In the present study, the expression levels of p38 were not affected by ischemia.
Neg (not) Regulation (affected) of p38 associated with ischemia
10) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.66 Pain Relevance 0.50
The total amount of p38, ERK, and JNK MAPK proteins were not affected following IL-1beta injection.
Neg (not) Regulation (affected) of p38
11) Confidence 0.24 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16033422 Disease Relevance 0.45 Pain Relevance 0.71
These results suggest that de novo synthesis of certain factors by NA through beta-adrenoceptors would participate in the modulation of p38 activity.
Regulation (modulation) of p38 associated with noradrenaline
12) Confidence 0.24 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0.17 Pain Relevance 0.37
Thus, mechanical hyperalgesia triggered by ET-1 in the rat hind paw depends importantly on signaling pathways involving PLC, PKC, p38 MAPK, ERK1/2, and JNK, whereas the contribution of PLA2 is relatively minor.
Regulation (depends) of p38 in paw associated with hyperalgesia
13) Confidence 0.21 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16741065 Disease Relevance 0.52 Pain Relevance 0.51
Using spontaneously diabetic Goto Kakizaki rats as a model of type 2 DM we investigated whether post-translational modifications in the Akt - FOXO3a pathway, Sirt1 - p53 pathway and the mitogen activated protein kinase p38 regulator are involved in post-infarct cardiac remodeling

Methods

Spec (whether) Regulation (regulator) of p38 associated with diabetes mellitus
14) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 0.99 Pain Relevance 0.04
Within the past decade, several studies in rodents have elucidated the roles of ERK, p38, JNK and ERK5 in generating nociceptive sensitivity and nociceptive plasticity.
Regulation (roles) of p38 associated with nociception
15) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 0.83 Pain Relevance 0.46
BDNF only blocked the phosphorylation of p38 at 6 hours and agmatine had no effect on phospho-p38 levels at any time points.
Neg (no) Regulation (effect) of p38
16) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.96 Pain Relevance 0
Another p38 inhibitor, CNI-1493, can activate the vagus when administered via intracerebroventricular injection, confirming the role of the p38 MAPK on vagal tone [25].
Regulation (role) of p38 associated with intracerebroventricular
17) Confidence 0.13 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927688 Disease Relevance 0.62 Pain Relevance 0.51
0.000) but lower than it in control group (Fig. 6).

7 Curcumin attenuates phospho-p38 but has no effect on phospho-JNK1/2 and phospho-Erk1/2

Neg (no) Regulation (as no ) of p38
18) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.23 Pain Relevance 0.53
We also observed the expression of both phospho-p38 and CB2 receptors in perivascular cells, suggesting that ECBs may also directly regulate p38 signaling in these cells.
Spec (may) Regulation (regulate) of p38 associated with endocannabinoid
19) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.46 Pain Relevance 0.69
Using this approach, we demonstrated that ECB signaling plays a functional role in the resolution of postoperative pain and in regulating the expression of glial cell markers and phosphorylated p38 (a MAPK associated with inflammation [18]).


Regulation (regulating) of p38 in glial cell associated with inflammation and perioperative pain
20) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.87 Pain Relevance 0.92

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