INT118915

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 2.26
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa5) DNA binding (Hoxa5)
Anatomy Link Frequency
central nervous system 2
dorsal 1
spinal cord 1
lamina 1
Hoxa5 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 45 100.00 Very High Very High Very High
Central nervous system 5 100.00 Very High Very High Very High
Pain 10 99.44 Very High Very High Very High
superficial lamina 5 98.84 Very High Very High Very High
substance P 5 90.68 High High
Dorsal horn 5 87.04 High High
Analgesic 5 75.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 10 99.84 Very High Very High Very High
Targeted Disruption 35 99.78 Very High Very High Very High
Pain 5 79.96 Quite High
Body Weight 5 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord show structural defects of the cervical spinal cord along with sensory and motor defects of the forelimb.
Gene_expression (expressing) of HOXA5 in dorsal associated with pain and spinal cord
1) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 15158076 Disease Relevance 0.44 Pain Relevance 0.51
Hoxa5 is also expressed in the spinal cord, yet no central nervous system phenotype has been described in Hoxa5 knockouts.
Gene_expression (expressed) of Hoxa5 in central nervous system associated with central nervous system and spinal cord
2) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.34 Pain Relevance 0.29
To identify the role of Hoxa5 in spinal cord development, we developed transgenic mice that express HOXA5 in the dorsal spinal cord in the brachial region.
Gene_expression (express) of HOXA5 in spinal cord associated with targeted disruption and spinal cord
3) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.40 Pain Relevance 0.31
Our evidence suggests apoptosis due to HOXA5 misexpression is a major cause of loss of superficial lamina cells in Hoxa5SV2 mice.
Gene_expression (misexpression) of HOXA5 in lamina associated with superficial lamina and apoptosis
4) Confidence 0.68 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.71 Pain Relevance 0.56
Hoxa5 is also expressed in the spinal cord, yet no central nervous system phenotype has been described in Hoxa5 knockouts.
Gene_expression (expressed) of Hoxa5 in central nervous system associated with central nervous system and spinal cord
5) Confidence 0.68 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.37 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox