INT118915

Context Info Confidence 0.78 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 5 Disease Relevance 2.26 Pain Relevance 1.98

nucleus (Hoxa5) DNA binding (Hoxa5)

Anatomy Link Frequency central nervous system 2 dorsal 1 spinal cord 1 lamina 1 Hoxa5 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 45 100.00 Central nervous system 5 100.00 Pain 10 99.44 superficial lamina 5 98.84 substance P 5 90.68 Dorsal horn 5 87.04 Analgesic 5 75.12

Disease Link Frequency Relevance Heat Apoptosis 10 99.84 Targeted Disruption 35 99.78 Pain 5 79.96 Body Weight 5 70.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transgenic mice ectopically expressing HOXA5 in the dorsal spinal cord show structural defects of the cervical spinal cord along with sensory and motor defects of the forelimb.

Gene_expression (expressing) of HOXA5 in dorsal associated with pain and spinal cord

1) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 15158076 Disease Relevance 0.44 Pain Relevance 0.51

Hoxa5 is also expressed in the spinal cord, yet no central nervous system phenotype has been described in Hoxa5 knockouts.

Gene_expression (expressed) of Hoxa5 in central nervous system associated with central nervous system and spinal cord

2) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.34 Pain Relevance 0.29

To identify the role of Hoxa5 in spinal cord development, we developed transgenic mice that express HOXA5 in the dorsal spinal cord in the brachial region.

Gene_expression (express) of HOXA5 in spinal cord associated with targeted disruption and spinal cord

3) Confidence 0.78 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.40 Pain Relevance 0.31

Our evidence suggests apoptosis due to HOXA5 misexpression is a major cause of loss of superficial lamina cells in Hoxa5SV2 mice.

Gene_expression (misexpression) of HOXA5 in lamina associated with superficial lamina and apoptosis

4) Confidence 0.68 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.71 Pain Relevance 0.56

Hoxa5 is also expressed in the spinal cord, yet no central nervous system phenotype has been described in Hoxa5 knockouts.

Gene_expression (expressed) of Hoxa5 in central nervous system associated with central nervous system and spinal cord

5) Confidence 0.68 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15158076 Disease Relevance 0.37 Pain Relevance 0.31

General Comments

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