INT118916

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.11
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SBDS) nucleoplasm (SBDS) nucleolus (SBDS)
rRNA binding (SBDS) cytoskeleton (SBDS) nucleus (SBDS)
Anatomy Link Frequency
SmI 2
spike 1
fibroblasts 1
upper 1
SBDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatosensory cortex 65 99.64 Very High Very High Very High
Chronic pancreatitis 5 98.36 Very High Very High Very High
imagery 19 96.48 Very High Very High Very High
antagonist 3 95.64 Very High Very High Very High
sodium channel 18 95.16 Very High Very High Very High
Thalamus 26 94.60 High High
lidocaine 5 94.56 High High
agonist 2 78.20 Quite High
Somatostatin 2 67.72 Quite High
rheumatoid arthritis 35 55.76 Quite High
Disease Link Frequency Relevance Heat
Syndrome 20 100.00 Very High Very High Very High
Pancreatic Cancer 5 99.24 Very High Very High Very High
Absence Epilepsy 31 99.08 Very High Very High Very High
Pancreatitis 5 98.36 Very High Very High Very High
Hematologic Neoplasms 5 98.32 Very High Very High Very High
Adrenal Cancer 182 94.40 High High
Cyst 43 86.24 High High
Convulsion 107 84.32 Quite High
Epilepsy 20 82.76 Quite High
Disease 33 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.
Gene_expression (Expression) of SBDS associated with syndrome, pancreatic cancer and chronic pancreatitis
1) Confidence 0.53 Published 2008 Journal Histol. Histopathol. Section Title Doc Link 18437680 Disease Relevance 0.59 Pain Relevance 0.10
In CP tissues, SBDS was found in the cytoplasm of ductal cells, tubular complexes, stromal fibroblasts and in PanIN1-2 lesions.
Gene_expression (found) of SBDS in fibroblasts
2) Confidence 0.53 Published 2008 Journal Histol. Histopathol. Section Body Doc Link 18437680 Disease Relevance 0.08 Pain Relevance 0
Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.
Gene_expression (Expression) of Shwachman-Bodian-Diamond syndrome associated with syndrome, pancreatic cancer and chronic pancreatitis
3) Confidence 0.53 Published 2008 Journal Histol. Histopathol. Section Title Doc Link 18437680 Disease Relevance 0.59 Pain Relevance 0.10
METHODS: In this study, the expression and localization of SBDS were investigated in normal human pancreatic tissues, chronic pancreatitis (CP) tissues, primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tissues, as well as in cultured pancreatic cancer cell lines by immunohistochemistry, immunoblotting and immunocytochemistry.
Spec (investigated) Gene_expression (expression) of SBDS
4) Confidence 0.53 Published 2008 Journal Histol. Histopathol. Section Body Doc Link 18437680 Disease Relevance 0.10 Pain Relevance 0
CONCLUSION: SBDS is expressed in normal, CP, and PDAC tissues, as well as in pancreatic cancer cell lines.
Gene_expression (expressed) of SBDS
5) Confidence 0.53 Published 2008 Journal Histol. Histopathol. Section Body Doc Link 18437680 Disease Relevance 0.07 Pain Relevance 0
In genetic models of absence epilepsy, recent in vivo investigations indicate that SWDs emerge first in the facial somatosensory cortex and then propagate via the corticothalamocortical loop.
Gene_expression (emerge) of SWDs in cortex associated with somatosensory cortex and absence epilepsy
6) Confidence 0.45 Published 2009 Journal Cereb. Cortex Section Abstract Doc Link 19276326 Disease Relevance 0.47 Pain Relevance 0.15
RLJ, NDK, SdS and JGW helped in preparation of the manuscript
Gene_expression (helped) of SdS
7) Confidence 0.38 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092434 Disease Relevance 0.73 Pain Relevance 0
It was hypothesized that functional deactivation of the SmI might reduce the appearance of SWDs.
Gene_expression (appearance) of SWDs in SmI associated with somatosensory cortex
8) Confidence 0.23 Published 2004 Journal Brain Res. Section Abstract Doc Link 15158169 Disease Relevance 0.16 Pain Relevance 0.73
SWD power was then scaled such as to be about zero between SWDs and about one during SWDs.
Gene_expression (one) of SWDs
9) Confidence 0.17 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2605917 Disease Relevance 0.24 Pain Relevance 0.11
Pharmacological studies in BACE1-/- mice exhibiting SWDs revealed that whereas phenytoin had no effect on spike-wave discharges, ethosuximide markedly reduced the frequency of these discharges (Fig. 1D).
Gene_expression (exhibiting) of SWDs in spike
10) Confidence 0.09 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.95 Pain Relevance 0.14
Mean FH SDS was ?
Gene_expression (Mean) of SDS
11) Confidence 0.06 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.45 Pain Relevance 0.07
Mean FH SDS was ?
Gene_expression (was) of SDS
12) Confidence 0.06 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.45 Pain Relevance 0.07
The produced and purified proteins of rLRP2-F2, -F3, and -F7, and rCD69 showed their expected molecular weights on staining with Ponceau S after SDS–PAGE separation and transfer to the membrane (Fig. 2, upper panel).
Gene_expression (transfer) of SDS in upper
13) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0.24 Pain Relevance 0.03

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