INT11892

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Context Info
Confidence 0.68
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.32
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
Anatomy Link Frequency
nerves 2
plasma 1
brainstem 1
neuromuscular junctions 1
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 14 99.92 Very High Very High Very High
substance P 9 99.28 Very High Very High Very High
Neuropeptide 8 99.08 Very High Very High Very High
Limbic system 2 97.60 Very High Very High Very High
Spinal cord 3 97.00 Very High Very High Very High
medulla 1 94.88 High High
Dopamine 5 94.56 High High
Central nervous system 6 94.08 High High
Thalamus 2 91.96 High High
Calcitonin gene-related peptide 3 91.88 High High
Disease Link Frequency Relevance Heat
Poisoning 10 99.36 Very High Very High Very High
Toxicity 8 99.22 Very High Very High Very High
Increased Venous Pressure Under Development 37 89.48 High High
Abdominal Pain 1 84.76 Quite High
Paralysis 4 81.68 Quite High
Vomiting 3 81.12 Quite High
Emergencies 1 79.40 Quite High
Cognitive Disorder 19 77.04 Quite High
Disease 70 75.20 Quite High
Dementia 10 66.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to aneurally cultured human muscle, which is immature in regard to its morphologic phenotype and only rarely and weakly contracts spontaneously, innervated cultured human muscle fibres have: (1) nearly continuous, d-tubocurarine-inhibitable contractions; (2) well-developed cross-striations, basal lamina, t-tubules, and postsynaptic folds of the neuromuscular junctions; (3) the majority of their nuclei peripheralized; and (4) acetylcholinesterase-positive sites present only at the neuromuscular junctions.
Gene_expression (present) of acetylcholinesterase in neuromuscular junctions
1) Confidence 0.68 Published 1992 Journal J. Neurocytol. Section Abstract Doc Link 1607877 Disease Relevance 0.14 Pain Relevance 0.18
In the present study, we carried out histochemical and immunohistochemical procedures in the Pa of normal individuals to visualize the pattern of distribution of acetylcholinesterase (AChE), calbindin D-28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), substance P (SP), and enkephalin (ENK).
Gene_expression (distribution) of AChE associated with enkephalin, limbic system and substance p
2) Confidence 0.62 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.38
In the present study, we carried out histochemical and immunohistochemical procedures in the Pa of normal individuals to visualize the pattern of distribution of acetylcholinesterase (AChE), calbindin D-28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), substance P (SP), and enkephalin (ENK).
Gene_expression (distribution) of acetylcholinesterase associated with enkephalin, limbic system and substance p
3) Confidence 0.62 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.38
The patient's plasma acetylcholinesterase level was checked, revealing 1498.6 microU/L (normal range: 2,000-5, 000) on the first day and 1,379 microU/L on the second day.
Gene_expression (level) of plasma acetylcholinesterase in plasma
4) Confidence 0.59 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1240170 Disease Relevance 0.51 Pain Relevance 0.08
The greatest density of nerves were acetylcholinesterase positive and immunoreactive to neuropeptide Y followed (in decreasing order) by nerves immunoreactive to: vasoactive intestinal polypeptide and dopamine beta-hydroxylase; leu-enkephalin and 5-hydroxytryptamine; calcitonin gene-related peptide; met-enkephalin; substance P; somatostatin.
Gene_expression (positive) of acetylcholinesterase in nerves associated with dopamine, somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
5) Confidence 0.48 Published 1991 Journal J. Urol. Section Abstract Doc Link 1719253 Disease Relevance 0 Pain Relevance 0.79
With the use of immunocytochemical staining and a constant supply of properly fixed human abortuses from southern China, an early appearance of acetylcholinesterase, enkephalin, and substance P immunoreactivities was detected first in the spinal cord (weeks 5 to 7 of gestation), then in the brainstem nuclei (weeks 11 to 12).
Gene_expression (appearance) of acetylcholinesterase in brainstem associated with medulla, enkephalin, spinal cord and substance p
6) Confidence 0.38 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10402266 Disease Relevance 0 Pain Relevance 0.66
The distinctive feature of NEB, not found with single NE cells, is the presence of nonmyelinated nerve endings in contact with granulated cells, and positive staining for acetylcholinesterase.
Gene_expression (staining) of acetylcholinesterase in nerve
7) Confidence 0.35 Published 1982 Journal Exp. Lung Res. Section Abstract Doc Link 6188605 Disease Relevance 0 Pain Relevance 0.12
In mammals, two cholinesterases exist: AChE, which selectively hydrolyzes ACh, and butyrylcholinesterase, which hydrolyzes other choline esters in addition to ACh.
Gene_expression (exist) of AChE
8) Confidence 0.33 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.40 Pain Relevance 0.03
The electrometric and colorimetric methods, which measure change in pH and light absorbance, respectively, most often measure AChE suppression.
Gene_expression (suppression) of AChE
9) Confidence 0.27 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665422 Disease Relevance 0.07 Pain Relevance 0
Organophosphorus ester pesticides (OPs) are well acknowledged to have the potential to result in severe, acute toxicity through the phosphorylation of serine residues of acetylcholinesterase (AChE) and the subsequent accumulation of ACh.
Gene_expression (residues) of AChE associated with toxicity
10) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2859412 Disease Relevance 0.10 Pain Relevance 0
Organophosphorus ester pesticides (OPs) are well acknowledged to have the potential to result in severe, acute toxicity through the phosphorylation of serine residues of acetylcholinesterase (AChE) and the subsequent accumulation of ACh.
Gene_expression (residues) of acetylcholinesterase associated with toxicity
11) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2859412 Disease Relevance 0.10 Pain Relevance 0

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