INT118926

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 5.79
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
chondrocytes 2
granulocytes 1
myometrium 1
monocytes 1
mononuclear phagocytes 1
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 100.00 Very High Very High Very High
Antinociceptive 5 99.98 Very High Very High Very High
cytokine 16 99.84 Very High Very High Very High
Inflammation 103 99.80 Very High Very High Very High
COX2 9 99.70 Very High Very High Very High
Osteoarthritis 133 99.60 Very High Very High Very High
Hyperalgesia 8 99.52 Very High Very High Very High
Delta opioid receptors 2 99.26 Very High Very High Very High
cINOD 37 98.56 Very High Very High Very High
COX-2 inhibitor 8 93.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 137 99.80 Very High Very High Very High
Cancer 15 99.80 Very High Very High Very High
Osteoarthritis 147 99.60 Very High Very High Very High
Hyperalgesia 8 99.52 Very High Very High Very High
Disease 18 96.64 Very High Very High Very High
Pain 21 95.48 Very High Very High Very High
Toxicity 2 93.28 High High
Colon Cancer 2 89.84 High High
Fever 10 85.48 High High
Nociception 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils.
Regulation (Regulation) of microsomal prostaglandin E synthase-1 in mononuclear phagocytes
1) Confidence 0.51 Published 2007 Journal J. Leukoc. Biol. Section Title Doc Link 17505022 Disease Relevance 0.53 Pain Relevance 0.37
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of mPGES-1 in granulocytes associated with cox2
2) Confidence 0.43 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.37 Pain Relevance 0.35
Collectively, these data suggest that Egr-1 may be one of the transcription factors involved in HNE-induced mPGES-1 promoter activity.


Regulation (involved) of mPGES-1 promoter
3) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.18 Pain Relevance 0.09
Exchange toward the human residues in rat MPGES1 was accompanied with a gain of inhibitor activity, whereas exchange in human MPGES1 toward the residues found in rat abrogated inhibitor activity.
Regulation (Exchange) of MPGES1
4) Confidence 0.38 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605783 Disease Relevance 0.26 Pain Relevance 0.27
On the other hand, rat MPGES1 containing residues 115–140 from the human enzyme, chimera rat115hum140rat, gained inhibitory potential and was affected by compound I with an IC50 value of 300 nm (Fig. 3B and Table 1).


Regulation (affected) of MPGES1
5) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0
Microsomal prostaglandin E synthase-1 (mPGES-1) is a promising target for development of next-generation anti-inflammatory drugs.
Regulation (target) of mPGES-1 associated with inflammation and cinod
6) Confidence 0.27 Published 2008 Journal J Phys Chem B Section Abstract Doc Link 18476739 Disease Relevance 0.19 Pain Relevance 0.19
Microsomal prostaglandin E synthase-1 (mPGES-1) is a promising target for development of next-generation anti-inflammatory drugs.
Regulation (target) of prostaglandin E synthase-1 associated with inflammation and cinod
7) Confidence 0.27 Published 2008 Journal J Phys Chem B Section Abstract Doc Link 18476739 Disease Relevance 0.19 Pain Relevance 0.19
This profile of mPGES-1 inhibition, distinct from COX-2 inhibition in cells, validates mPGES-1 as an attractive target for therapeutic intervention.
Regulation (target) of mPGES-1
8) Confidence 0.27 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.29 Pain Relevance 0.19
Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour.
Regulation (regulation) of prostaglandin E synthase in myometrium associated with cox2
9) Confidence 0.26 Published 2007 Journal Mol. Hum. Reprod. Section Title Doc Link 17105783 Disease Relevance 0.10 Pain Relevance 0.34
Induction of mPGES-1 and its modulation by cytokines were confirmed at the protein level and correlated with PGE(2) production.
Regulation (modulation) of mPGES-1 associated with cytokine
10) Confidence 0.26 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.41 Pain Relevance 0.36
mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators".
Regulation (target) of mPGES-1 associated with cancer
11) Confidence 0.26 Published 2010 Journal Biochimie Section Title Doc Link 20159031 Disease Relevance 0.70 Pain Relevance 0.20
This review will focus on recent efforts to target the terminal synthase, mPGES-1, for cancer chemoprevention.
Regulation (target) of mPGES-1 associated with cancer
12) Confidence 0.26 Published 2010 Journal Biochimie Section Abstract Doc Link 20159031 Disease Relevance 0.77 Pain Relevance 0.21
In the present study, we investigated the effects of HNE on COX-2/mPGES-1 and 5-LOX pathways regulation in human OA chondrocytes.
Spec (investigated) Regulation (regulation) of mPGES-1 in chondrocytes associated with osteoarthritis
13) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.32
Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes

Introduction

Regulation (Regulation) of microsomal prostaglandin E2 synthase-1 in chondrocytes associated with osteoarthritis
14) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Title Doc Link PMC2875653 Disease Relevance 0.18 Pain Relevance 0.03
Differences in these positions in rat and mouse MPGES1 but not in other rodent orthologues to the human enzyme explain the selective inhibition pattern of compound I.
Regulation (Differences) of MPGES1
15) Confidence 0.21 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of mPGES-1 in monocytes associated with cox2
16) Confidence 0.15 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.37 Pain Relevance 0.35
Prostaglandin E synthase: a novel drug target for inflammation and cancer.
Regulation (target) of Prostaglandin E synthase associated with pain, inflammation and cancer
17) Confidence 0.08 Published 2006 Journal Curr. Pharm. Des. Section Title Doc Link 16533161 Disease Relevance 0.27 Pain Relevance 0.29
Real time PCR analysis indicated that there were no differences in the expression of cyclooxygenase-2 (COX-2), aldoketoreductase 1B5 (AKR1B5), prostaglandin E synthase (PGES), hydroxyprostaglandin-15 dehydrogenase (PGDH) and PGE2 -9-reductase as a function of PKCepsilon down-regulation.
Regulation (regulation) of PGES
18) Confidence 0.03 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0
These data indicate that peripheral kappa- and delta-opioid receptors are involved in the antinociceptive effect of Crotalus durissus terrificus on prostaglandin E(2)-induced hyperalgesia.
Regulation (effect) of prostaglandin E associated with hyperalgesia, delta opioid receptors and antinociceptive
19) Confidence 0.00 Published 2004 Journal Life Sci. Section Abstract Doc Link 15158366 Disease Relevance 0.35 Pain Relevance 0.95

General Comments

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