INT118927

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal 2
cortex 2
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 1 100.00 Very High Very High Very High
Spinal cord 21 98.64 Very High Very High Very High
bDMF 32 98.00 Very High Very High Very High
Inflammation 26 97.84 Very High Very High Very High
Eae 52 95.64 Very High Very High Very High
Dorsal horn neuron 13 93.20 High High
Kinase C 1 92.64 High High
adenocard 1 90.28 High High
antidepressant 115 89.20 High High
Desipramine 4 88.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 97.84 Very High Very High Very High
Inflammatory Pain 28 95.64 Very High Very High Very High
Depression 92 85.52 High High
Targeted Disruption 27 80.80 Quite High
Urological Neuroanatomy 4 63.64 Quite High
Syndrome 2 56.48 Quite High
Frailty 1 45.68 Quite Low
Hypersensitivity 16 43.20 Quite Low
Stress 10 32.08 Quite Low
Nociception 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: After single injection, we found that FGF-2 mRNA levels were selectively upregulated in the prefrontal cortex only when the two drugs were coadministered, an effect paralleled by a significant increase of phosphorylated protein kinase B (P-Akt) levels.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of kinase B in cortex
1) Confidence 0.04 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
Protein kinase A phosphorylation of GluR1 Ser845 promotes the surface-expression of GluR1 in cultured hippocampal neurons during activity-dependent long-term potentiation [35] and might also be responsible for spinal GluR1 membrane insertion in vivo following CFA-induced inflammation.
Spec (might) Positive_regulation (responsible) of Phosphorylation (phosphorylation) of Protein kinase in spinal associated with inflammation and long-term potentiation
2) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.46 Pain Relevance 0.56
As the name suggests, it involves the cAMP cascade and cAMP dependent protein kinase for activation and phosphorylation respectively [95, 209].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of protein kinase
3) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.30 Pain Relevance 0.82

General Comments

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