INT11893

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 96
Total Number 99
Disease Relevance 31.49
Pain Relevance 21.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 24
blood 4
brain 2
joints 2
lungs 2
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 70 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
cytokine 145 99.98 Very High Very High Very High
nociceptor 7 99.90 Very High Very High Very High
agonist 331 99.86 Very High Very High Very High
COX2 88 99.80 Very High Very High Very High
Calcitonin gene-related peptide 73 99.80 Very High Very High Very High
Central nervous system 39 99.58 Very High Very High Very High
Locus ceruleus 32 99.58 Very High Very High Very High
noradrenaline 8 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1078 100.00 Very High Very High Very High
Injury 57 99.86 Very High Very High Very High
Multiple Sclerosis 396 99.68 Very High Very High Very High
Stress 287 99.68 Very High Very High Very High
Respiratory Failure 3 99.64 Very High Very High Very High
Urological Neuroanatomy 41 99.62 Very High Very High Very High
Disease 232 99.60 Very High Very High Very High
Toxicity 43 99.52 Very High Very High Very High
Brain Injury 20 99.52 Very High Very High Very High
Colon Cancer 10 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of these data, collectively, supports the hypothesis that prostaglandins regulate trigeminal TRPV(1) nociceptors via activation of the EP2 and EP3 receptors.
Positive_regulation (activation) of EP2 in nociceptors associated with nociceptor
1) Confidence 0.69 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.11 Pain Relevance 0.54
We found that cell profiles immunoreactive (IR) for four EP receptors, EP1, EP2, EP3, and EP4, are dramatically increased in injured nerve 2 and 4 weeks after PSNL.
Positive_regulation (increased) of EP2 in nerve
2) Confidence 0.52 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.24 Pain Relevance 0.44
A longitudinal section of myometrium was removed, total RNA was extracted, and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed for glyceraldehyde phosphate dehydrogenase (GAPDH), calponin, EP2, and FP receptor mRNA expression.
Positive_regulation (performed) of EP2 in myometrium
3) Confidence 0.48 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0.07 Pain Relevance 0.07
We have recently reported that PGE2 excited SON neurones by directly activating postsynaptic PGE2 receptors (EP receptors) of a subclass other than EP1-3, but did not affect excitatory postsynaptic currents (EPSCs).
Positive_regulation (activating) of PGE2 in PGE2
4) Confidence 0.43 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10520139 Disease Relevance 0 Pain Relevance 0.06
However, the increase observed in PGE2 is about three-fold higher in LPS plus NE than with LPS alone.
Positive_regulation (increase) of PGE2
5) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.24 Pain Relevance 0.28
COX-2 expression is elevated in the AD brains [14,18] and PGE2 is accumulated in the cerebrospinal fluid of AD patients [61].
Positive_regulation (accumulated) of PGE2 in brains associated with disease
6) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.98 Pain Relevance 0.16
This study demonstrates a significant elevation of renal PGE2 in patients undergoing standard anaesthesia during surgery.
Positive_regulation (elevation) of PGE2
7) Confidence 0.37 Published 1985 Journal Eur J Anaesthesiol Section Abstract Doc Link 3910429 Disease Relevance 0 Pain Relevance 0.39
Fifteen minutes after injury, both PGE2 and TxB2 levels remained elevated but the levels were lower than at 5 min in the rats that did not exhibit posttraumatic seizures.
Positive_regulation (elevated) of PGE2 in PGE2 associated with convulsion and injury
8) Confidence 0.35 Published 1988 Journal J. Neurotrauma Section Abstract Doc Link 3249309 Disease Relevance 0.86 Pain Relevance 0.14
It seems that some of the mechanisms underlying inflammation-induced plastic changes are mediated by time-dependent increase in PGE2 concentration, activation of EP1 receptors, and increase in [Ca2+]i in the spinal dorsal horn.


Positive_regulation (increase) of PGE2 in PGE2
9) Confidence 0.32 Published 2002 Journal Anesthesiology Section Body Doc Link 12411813 Disease Relevance 0 Pain Relevance 0
CTGF and Ptger2 were increased in SHR vs.
Positive_regulation (increased) of Ptger2
10) Confidence 0.32 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.05 Pain Relevance 0
They found that although EP1, 2, 3C and 4 are expressed in DRG neurons, as observed by others [54], only EP3C and EP4 receptor subtypes mediate the PGE2-induced cAMP production and increased release of substance P and CGRP.
Positive_regulation (mediate) of PGE2 in neurons associated with dorsal root ganglion and substance p
11) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.31 Pain Relevance 0.36
PGE2 potentiation is mediated by PKA
Positive_regulation (potentiation) of PGE2
12) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.33
Two minutes after PGE2, fast ATP currents were increased by 48%, reaching a saturating value 10 min later.
Positive_regulation (increased) of PGE2
13) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0
After 10 min pretreatment with H89, PGE2 no longer could enhance ATP currents (Figs. 5A and 5D), suggesting that PKA is involved in the modulatory action of PGE2.
Positive_regulation (action) of PGE2
14) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0 Pain Relevance 0.05
In order to measure PGE2 potentiation before PKA-I reached the cell interior, patch electrodes of small tips (electrode resistance = 7–8 Mohm) were used to slow the intracellular perfusion of PKA-I.
Positive_regulation (potentiation) of PGE2
15) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.05 Pain Relevance 0.03
Thus, fluid percussion brain injury results in substantial elevations in PGE2 and TxB2 levels and posttraumatic seizures exacerbate the observed increases.
Positive_regulation (elevations) of PGE2 in PGE2 associated with convulsion and brain injury
16) Confidence 0.30 Published 1988 Journal J. Neurotrauma Section Abstract Doc Link 3249309 Disease Relevance 0.83 Pain Relevance 0.09
In these animals the quantification of proinflammatory mediators in the CSF revealed a significant increase in both PGE2 and TNF-alpha concentrations.
Positive_regulation (increase) of PGE2 in PGE2
17) Confidence 0.29 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17377112 Disease Relevance 0.07 Pain Relevance 0
The enhancement of PGE2 induced by NE in LPS-stimulated microglia, but not by NE alone, confirms the previous results in which NE in combination with LPS further increased COX-2 immunoreactivity whereas NE alone did not increase COX-2 protein levels.


Positive_regulation (enhancement) of PGE2 in microglia
18) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.03
M alone, did not lead to an increase in PGE2 over 24 h.
Positive_regulation (increase) of PGE2
19) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
Next, we investigated whether the increased intracellular levels of COX-2 evoked by LPS plus NE causes elevated levels of PGE2.
Spec (whether) Positive_regulation (levels) of PGE2
20) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.28

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