INT11894

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Context Info
Confidence 0.55
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 47
Total Number 47
Disease Relevance 16.95
Pain Relevance 11.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
microglia 10
PGE2 6
chondrocytes 4
macrophages 2
neurons 2
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 515 100.00 Very High Very High Very High
aspirin 34 100.00 Very High Very High Very High
Hyperalgesia 22 100.00 Very High Very High Very High
depression 1 100.00 Very High Very High Very High
Opioid 2 99.74 Very High Very High Very High
Analgesic 21 99.62 Very High Very High Very High
cINOD 98 99.48 Very High Very High Very High
Inflammatory response 129 99.40 Very High Very High Very High
Osteoarthritis 155 99.28 Very High Very High Very High
Pain 54 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 694 100.00 Very High Very High Very High
Hyperalgesia 22 100.00 Very High Very High Very High
Depression 1 100.00 Very High Very High Very High
Osteoarthritis 170 99.28 Very High Very High Very High
Pain 61 98.96 Very High Very High Very High
Neurodegenerative Disease 10 98.28 Very High Very High Very High
Rheumatoid Arthritis 17 97.96 Very High Very High Very High
Post Operative Pain 1 97.60 Very High Very High Very High
Disease 67 96.52 Very High Very High Very High
Necrosis 17 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EP2 receptor mRNA expression was highest at Day 16 and declined significantly to Day 21.5 and one day postpartum (p < 0.05, Student-Newman-Keuls procedure).
Negative_regulation (declined) of Gene_expression (expression) of EP2 receptor mRNA
1) Confidence 0.55 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0.06 Pain Relevance 0.06
Myometrial activity at parturition may change from an active quiescent to an active contractile state in concert with a decline in expression of the relaxatory EP2 receptors and up-regulation of contractile FP receptors.
Negative_regulation (decline) of Gene_expression (expression) of EP2
2) Confidence 0.48 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746738 Disease Relevance 0 Pain Relevance 0
The He-Ne laser therapy reduced the synthesis of PGE2.
Negative_regulation (reduced) of Gene_expression (synthesis) of PGE2
3) Confidence 0.40 Published 1996 Journal J Clin Laser Med Surg Section Abstract Doc Link 9456634 Disease Relevance 0.24 Pain Relevance 0.25
We also assessed, by enzyme immunoassay, the effects of the combination on peripheral PGE-2 levels: CAF did not alter the inhibitory effect of ASA on PGE-2 synthesis.
Negative_regulation (effect) of Gene_expression (synthesis) of PGE-2 associated with aspirin
4) Confidence 0.37 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17507271 Disease Relevance 1.10 Pain Relevance 0.69
To establish the role of mesangial prostaglandin (PG) synthesis in the modulation of contractile responses, we studied the effects of the stable thromboxane A2/endoperoxide analogue U-46619 on cultured rat mesangial cells preincubated with 1) four structurally unrelated, nonsteroidal anti-inflammatory drugs, indomethacin, acetylsalicylic acid, meclofenamate, and piroxicam, to inhibit the synthesis of PGE2, the major mesangial metabolite of arachidonic acid; 2) exogenous PGE2 and the stable analogue of PGI2, iloprost; and 3) indomethacin in the presence of exogenous PGE2.
Negative_regulation (inhibit) of Gene_expression (synthesis) of PGE2 in mesangial cells associated with aspirin, inflammation and cinod
5) Confidence 0.30 Published 1988 Journal Circ. Res. Section Abstract Doc Link 3282714 Disease Relevance 0.17 Pain Relevance 0.26
Agents reducing PGE2 synthesis in in vitro and in vivo models of chronic neurodegenerative diseases like Parkinson's disease or AD have been demonstrated to be neuroprotective due to their anti-inflammatory effects [47-52].
Negative_regulation (reducing) of Gene_expression (synthesis) of PGE2 associated with inflammation, disease and neurodegenerative disease
6) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.51 Pain Relevance 0.27
To elucidate whether one of these parameters affect the other, the AM incubations with particles were performed in the absence and presence of indomethacin, an inhibitor of PGE2 synthesis.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of PGE2
7) Confidence 0.16 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.18 Pain Relevance 0.09
On the other hand, the levels of PGE-2 in the inflamed hind-paw were unaffected by the administration of this bisphosphonate.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of PGE-2 in paw
8) Confidence 0.15 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17664076 Disease Relevance 0.90 Pain Relevance 0.87
Benoxaprofen, also a non-steroidal anti-inflammatory drug, inhibited both PGE2 and iSRS production in a dose-dependent manner, but inhibition of the iSRS biosynthesis was three times more effective than inhibition of PGE2 production.
Negative_regulation (inhibition) of Gene_expression (production) of PGE2 associated with inflammation
9) Confidence 0.14 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6315014 Disease Relevance 0.39 Pain Relevance 0.28
The non-steroidal anti-inflammatory drugs indomethacin and aspirin inhibited PGE2 synthesis by RBL-1 cells, which had been stimulated with the calcium ionophore A-23187, in a dose-dependent manner with an IC50 of 0.7 and 7.8 microM respectively.
Negative_regulation (inhibited) of Gene_expression (synthesis) of PGE2 in RBL-1 associated with aspirin, inflammation and cinod
10) Confidence 0.14 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6315014 Disease Relevance 0.41 Pain Relevance 0.30
The IC50 values for inhibition of iSRS production were 0.2 microM (gossypol), 0.5 microM (BW755c), 0.6 microM (BHA), and 0.6 microM (NDGA) compared to 2.8 microM (gossypol), 2.0 microM (BW755c), 4.8 microM (BHA) and 2.6 microM (NDGA) for inhibition of PGE2 synthesis.
Negative_regulation (inhibition) of Gene_expression (synthesis) of PGE2
11) Confidence 0.14 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6315014 Disease Relevance 0.28 Pain Relevance 0.32
The supernatants of particle-treated AM, containing PGE2, reduced the respiratory burst activity of stimulated neutrophils, which was restored to control level when PGE2 production was prevented in AM by COX inhibitors [8].
Negative_regulation (prevented) of Gene_expression (production) of PGE2 in neutrophils
12) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.35 Pain Relevance 0.18
However, inhibition by indomethacin abolished these significant differences of PGE2 production for both types of particles due to the inhibition of PGE2 synthesis.
Negative_regulation (inhibition) of Gene_expression (synthesis) of PGE2
13) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.38 Pain Relevance 0.10
m particles, it can be concluded that the inflammatory response of small Fe2O3 particles was inhibited due to higher PGE2 production caused by higher levels of soluble iron within AM.
Negative_regulation (inhibited) of Gene_expression (production) of PGE2 associated with inflammatory response
14) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.39 Pain Relevance 0.23
m Fe2O3 particles in the presence of PGE2 synthesis inhibitor, indomethacin.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of PGE2
15) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.35 Pain Relevance 0.22
Results from these experiments suggest that since an opioid peptide can lower endogenous PGE2 production in islets and since the stimulatory effects of the opioid peptide are reversed by exogenous PGE2 there may be interactions between these two modulators of insulin secretion.
Negative_regulation (lower) of Gene_expression (production) of PGE2 associated with opioid
16) Confidence 0.11 Published 1988 Journal Life Sci. Section Abstract Doc Link 2898715 Disease Relevance 0 Pain Relevance 0.49
In addition, syringaresinol, the hydrolysate of liriodendrin, more potently inhibited the LPS-induced production of NO, PGE 2 and TNF-alpha production of macrophages than liriodendrin.
Negative_regulation (inhibited) of Gene_expression (production) of PGE 2 in macrophages
17) Confidence 0.09 Published 2003 Journal Planta Med. Section Abstract Doc Link 12898415 Disease Relevance 0.33 Pain Relevance 0.33
The expressions of EP 2, EP 4, and EP 3 were further elevated or reduced in neurons treated with high K(+) for 24 hr.
Negative_regulation (reduced) of Gene_expression (expressions) of EP 2 in neurons
18) Confidence 0.09 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16041798 Disease Relevance 0 Pain Relevance 0.36
ML3000 (0.3, 1, 3, 10, 30 microg/ml) and indomethacin (0.3, 1, 3, 10, 30 microg/ml) concentration-dependently inhibited the synthesis of PGE2 (IC50 = 3.9 and 4.5 microM).
Negative_regulation (inhibited) of Gene_expression (synthesis) of PGE2
19) Confidence 0.06 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12005204 Disease Relevance 0 Pain Relevance 0
Such a mechanism would be consistent with the ability of 15d-PGJ2 to inhibit PGE2 production and to downregulate mPGES-1 in microsomal fractions from CHO cells overexpressing mPGES [26].
Negative_regulation (inhibit) of Gene_expression (production) of PGE2
20) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.56 Pain Relevance 0.33

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