INT118947

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.44
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (FABP4) lipid particle (FABP4) nucleus (FABP4)
lipid metabolic process (FABP4) cytoplasm (FABP4)
Anatomy Link Frequency
enterocyte 1
plasma 1
FABP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 99.50 Very High Very High Very High
ischemia 6 95.48 Very High Very High Very High
Angina 2 93.20 High High
agonist 113 92.00 High High
cINOD 41 76.32 Quite High
Morphine 2 53.16 Quite High
Paracetamol 5 52.64 Quite High
Analgesic 2 52.04 Quite High
Inflammation 18 5.00 Very Low Very Low Very Low
Potency 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 21 99.20 Very High Very High Very High
Liposarcoma 20 99.12 Very High Very High Very High
Death 7 98.76 Very High Very High Very High
Disorders Of Creatine Metabolism 12 97.84 Very High Very High Very High
Diuresis 6 97.64 Very High Very High Very High
Disease Progression 5 95.92 Very High Very High Very High
Cv Unclassified Under Development 4 95.48 Very High Very High Very High
Cancer 90 94.96 High High
Angina 2 93.20 High High
Disease 32 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For FABP, both sensitivity and negative predictive value (NPV) increased quickly to 100% for samples monitored just one hour after admission.
Positive_regulation (increased) of FABP
1) Confidence 0.67 Published 2004 Journal Z Kardiol Section Abstract Doc Link 15160274 Disease Relevance 1.18 Pain Relevance 0.10
Immunochemically assayed FABP, cardiac troponin I (cTnI) and enzymatically assayed creatine phosphokinase (CPK) were determined serially in plasma and serum samples from 218 patients presenting with chest pain and suspected MI.
Positive_regulation (assayed) of FABP in plasma associated with angina, disorders of creatine metabolism and myocardial infarction
2) Confidence 0.48 Published 2004 Journal Z Kardiol Section Abstract Doc Link 15160274 Disease Relevance 1.14 Pain Relevance 0.14
Diuresis during and after surgery was adequate (Table 1) and plasma creatinine values were not elevated, which indicates that elevation of plasma FABP was caused by enterocyte cell death.


Positive_regulation (elevation) of FABP in enterocyte associated with diuresis and death
3) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.25 Pain Relevance 0
Measurements of FABP and claudin-3
Positive_regulation (Measurements) of FABP
4) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2599890 Disease Relevance 0.05 Pain Relevance 0.16
increased at week 12, FABP at
Positive_regulation (increased) of FABP
5) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 0.82 Pain Relevance 0
antagonist, suppressed 24-mediated induction of both L-FABP and aP2.
Positive_regulation (induction) of aP2 associated with antagonist
6) Confidence 0.08 Published 2008 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2651753 Disease Relevance 0 Pain Relevance 0.29
Induction of L-FABP and aP2 was suppressed by pretreatment with 30 (GW9662)22 (Figure 5), a PPAR?
Positive_regulation (Induction) of aP2
7) Confidence 0.08 Published 2008 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2651753 Disease Relevance 0 Pain Relevance 0.25
Compound 24 induced both L-FABP and aP2 (Figure 4a) over the same concentration range that stimulated PPAR?
Positive_regulation (induced) of aP2
8) Confidence 0.04 Published 2008 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2651753 Disease Relevance 0 Pain Relevance 0.13

General Comments

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