INT118952

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.21
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.58
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hist1h3f) molecular_function (Hist1h3f) biological_process (Hist1h3f)
Anatomy Link Frequency
striatum 2
fibroblasts 1
oocytes 1
respiratory 1
Hist1h3f (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 9 98.52 Very High Very High Very High
cocaine 9 98.12 Very High Very High Very High
opiate 2 97.04 Very High Very High Very High
depression 74 94.76 High High
Dopamine 21 91.84 High High
Hippocampus 78 87.44 High High
chemokine 10 76.68 Quite High
Morphine 6 75.00 Quite High
antidepressant 62 54.48 Quite High
dexamethasone 6 31.28 Quite Low
Disease Link Frequency Relevance Heat
Stress 27 99.38 Very High Very High Very High
Mantle-cell Lymphoma 1 98.68 Very High Very High Very High
Hyperplasia 7 96.40 Very High Very High Very High
Follicular Lymphoma 1 96.12 Very High Very High Very High
Depression 96 94.76 High High
Polycystic Ovary Syndrome 3 91.00 High High
Osteogenic Sarcomas 1 90.04 High High
Ovarian Hyperstimulation Syndrome 2 89.32 High High
Cancer 152 87.04 High High
Lymphatic System Cancer 22 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar viral vector overexpression of full length HDAC4 in the striatum of mice led to reduced levels of histone H3 acetylation in the tissue and decreased the rewarding effects of cocaine in the place conditioning assay [29].
Gene_expression (acetylation) of histone H3 in striatum associated with cocaine
1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 0.05 Pain Relevance 0.17
As shown in Figure 5, VPA markedly increased acetyl-histone H3 expression with maximal induction at 12 h of incubation with VPA.
Gene_expression (expression) of acetyl-histone H3
2) Confidence 0.21 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.27 Pain Relevance 0
Effects of VPA on acetyl-histone H3 level, cell cycle regulatory protein
Gene_expression (level) of acetyl-histone H3
3) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.20 Pain Relevance 0
ERK activation induces the phosphorylation in the nucleus of mitogen- and stress-activated kinase-1 (MSK1) and histone H3, responses that are also restricted to D1R-expressing MSNs of the dorsal striatum and the NAc after cocaine (Bertran-Gonzalez et al., 2008).
Gene_expression (expressing) of histone H3 in striatum associated with stress, nucleus accumbens and cocaine
4) Confidence 0.17 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.16 Pain Relevance 0.30
As primary antibodies, a rabbit polyclonal HDAC1 antibody (1:5000) (Santa Cruz Biotechnology Inc., Santa Cruz, CA), rabbit polyclonal HDAC2 antibody (1:5000) (Santa Cruz), rabbit polyclonal acetyl-histone H3 (Lys 9) antibody (1:5000) (Cell Signaling, Beverly, MA), mouse monoclonal acetyl ?
Gene_expression (antibody) of acetyl-histone H3
5) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.36 Pain Relevance 0
In order to examine the DNA-damage induced G2/M checkpoint response in Mcph1gt/gt mouse fibroblasts, phospho-histone H3 (Ser10) (p-H3) expression was studied as a mitotic marker.
Gene_expression (expression) of phospho-histone H3 in fibroblasts
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.09 Pain Relevance 0
To investigate the influences of IVM on epigenetic reprogramming and to search for the possible reasons for the lower rates of fertilization and cleavage in IVM oocytes, we examined the expression of two enzymes controlling histone acetylation, histone acetyltransferase GCN5 (GCN5) and histone deacetylase 1 (HDAC1), as well as their common target, acetyl-histone H3 (Ac-H3), in mouse metaphase II (MII) oocytes and preimplantation embryos.
Spec (examined) Gene_expression (expression) of histone H3 in oocytes
7) Confidence 0.12 Published 2010 Journal Obstetrics and Gynecology International Section Abstract Doc Link PMC2896857 Disease Relevance 0.27 Pain Relevance 0
A western blot was prepared using the nuclear and cytosolic extracts and probed for the nuclear proteins histone H3 and lamin A/C.
Gene_expression (probed) of histone H3
8) Confidence 0.11 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.05 Pain Relevance 0
To this end, we examined the expression of two endogenous cell cycle markers in relation to BrdU: proliferating cell nuclear antigen (PCNA) and phosphorylated histone H3 (pHisH3).
Spec (examined) Gene_expression (expression) of phosphorylated histone H3
9) Confidence 0.10 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15160390 Disease Relevance 0 Pain Relevance 0.30
An increase in the acetylation levels of histone H3 with a maximum effect 8 h after dosing could be seen, but also only in the 200-mg cohort.
Gene_expression (levels) of histone H3
10) Confidence 0.07 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.98 Pain Relevance 0
While the majority of the Sca-1-expressing cells did not show evidence of active proliferation, a rare subset of the Sca-1 positive cells coexpressed phospho-histone H3 (Fig.
Gene_expression (coexpressed) of phospho-histone H3
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Of the respiratory epithelial cells expressing Sox17, 28% coexpressed phospho-histone H3 (Fig.
Gene_expression (coexpressed) of phospho-histone H3 in respiratory
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
Dual immunofluorescence revealed colocalized expression of phospho-histone H3 with Sox17, demonstrating that proliferation occurs within the Sox17-expressing population of cells in CCSPrtTA/tetO-Sox17 mice (Fig. 3M–O).
Gene_expression (expression) of phospho-histone H3
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.10 Pain Relevance 0
They also reported that the levels of acetylated histone H3 were decreased in the promoters of I, IV, and VI exons, suggesting that histone acetylation is involved in regulation of the Bdnf gene in the immobilization stress model.
Gene_expression (levels) of histone H3 associated with stress
14) Confidence 0.05 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.66 Pain Relevance 0.13
In vitro treatment with CXCL12 did not increase phospho-histone H3 levels or alter nestin or ?
Gene_expression (levels) of phospho-histone H3
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox