INT11896

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 1981
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 6.01
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
platelet 4
plasma 3
cortex 1
hippocampus 1
PGE2 1
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 3 100.00 Very High Very High Very High
depression 3 100.00 Very High Very High Very High
cINOD 40 99.98 Very High Very High Very High
aspirin 11 99.98 Very High Very High Very High
cva 4 99.52 Very High Very High Very High
anesthesia 10 99.44 Very High Very High Very High
acular 11 99.32 Very High Very High Very High
ischemia 5 98.60 Very High Very High Very High
Hippocampus 28 97.92 Very High Very High Very High
Angina 21 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 3 100.00 Very High Very High Very High
Cv General 3 Under Development 21 99.52 Very High Very High Very High
Cv Unclassified Under Development 5 98.60 Very High Very High Very High
Cancer 1 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 4 95.36 Very High Very High Very High
Disease 85 94.80 High High
Hemorrhage 6 94.68 High High
Malignant Neoplastic Disease 2 94.48 High High
Myocardial Infarction 2 94.16 High High
Muscular Spasm 2 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although antiplatelet agent will block all TxB2 release even in VO, their clinical potential seems greatest in VA.
Negative_regulation (block) of TxB2 associated with angina
1) Confidence 0.11 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 0.80 Pain Relevance 0.50
TxB2 levels decreased markedly in the KT group from 106.9 +/- 96.2 ng/mL preoperatively to 0.4 +/- 1.2 ng/mL poststudy drug, P = 0.002.
Negative_regulation (decreased) of TxB2 associated with acular
2) Confidence 0.07 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7598238 Disease Relevance 0.19 Pain Relevance 1.32
In cardiopulmonary bypass, TxB2 level were markedly elevated ten minutes after beginning, and then decreased gradually until the end of cardiopulmonary bypass.
Negative_regulation (decreased) of TxB2
3) Confidence 0.04 Published 1985 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 2935731 Disease Relevance 0.69 Pain Relevance 0.12
CONCLUSION: Propacetamol 60 mg kg(-1) i.v. causes reversible platelet dysfunction demonstrated by a decrease in maximal platelet aggregation and TxB2 concentration.
Negative_regulation (decrease) of TxB2 in platelet
4) Confidence 0.02 Published 2000 Journal Acta Anaesthesiol Scand Section Body Doc Link 10669275 Disease Relevance 0 Pain Relevance 0
During spontaneous breathing there was a decrease in plasma PGE2 and TxB2 concentrations.
Negative_regulation (decrease) of TxB2 in plasma
5) Confidence 0.01 Published 1987 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3478740 Disease Relevance 0.08 Pain Relevance 0.16
Compared with placebo, Tg2576 mice receiving indomethacin plus vitamin E at the same time had a significant reduction in PGE2 and suppression of TxB2 levels in tissue homogenates from total cortex and hippocampus (Table 1).
Negative_regulation (suppression) of TxB2 in cortex associated with hippocampus
6) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527877 Disease Relevance 0.33 Pain Relevance 0.13
Administration of gallopamil (50 mg kg-1 three times a day for 30 days) reduced plasma levels of catecholamines, beta-thromboglobulin and TxB2 blood concentrations either under basal conditions or after CPT.
Negative_regulation (reduced) of TxB2 in plasma associated with catecholamine
7) Confidence 0.00 Published 1995 Journal Pharmacol. Res. Section Abstract Doc Link 8668647 Disease Relevance 0.42 Pain Relevance 0.49
Compared with placebo, Tg2576 mice receiving indomethacin plus vitamin E at the same time had a significant reduction in PGE2 and suppression of TxB2 levels in tissue homogenates from total cortex and hippocampus (Table 1).
Negative_regulation (suppression) of TxB2 in hippocampus associated with hippocampus
8) Confidence 0.00 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527877 Disease Relevance 0.33 Pain Relevance 0.13
There were 129 transient ischemic episodes during control and 146 after aspirin, when platelet TxB2 was reduced to negligible levels.
Negative_regulation (reduced) of TxB2 in platelet associated with aspirin
9) Confidence 0.00 Published 1982 Journal Circulation Section Abstract Doc Link 7116586 Disease Relevance 0.57 Pain Relevance 0.29
All patients underwent continuous ECG monitoring for 2 days before and 2 days after a single, low, i.v. dose of aspirin (2 mg/kg), which reduced TxB2 (the stable metabolite of TxA2) to less than 3% of the control values.
Negative_regulation (reduced) of TxB2 associated with aspirin
10) Confidence 0.00 Published 1982 Journal Circulation Section Abstract Doc Link 7116586 Disease Relevance 0.61 Pain Relevance 0.30
Valdecoxib had no platelet effects, while ibuprofen significantly decreased platelet aggregation, significantly increased bleeding time (2-4 h postdose on each day), and significantly decreased TxB2 levels at all time points.
Negative_regulation (decreased) of TxB2 in platelet associated with cva
11) Confidence 0.00 Published 2003 Journal J Clin Pharmacol Section Abstract Doc Link 12751271 Disease Relevance 0.27 Pain Relevance 0.17
Unlike celecoxib or placebo, naproxen produced statistically significant reductions in platelet aggregation and serum TxB2 levels and increased bleeding time.
Negative_regulation (reductions) of TxB2 in platelet associated with cva
12) Confidence 0.00 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10664917 Disease Relevance 0.33 Pain Relevance 0.48
Overall, there was a significant depression in the CF levels of both PGE2 and TxB2 in all NSAID-treated groups.
Negative_regulation (depression) of TxB2 in PGE2 associated with depression and cinod
13) Confidence 0.00 Published 1992 Journal J. Periodont. Res. Section Abstract Doc Link 1608034 Disease Relevance 0.46 Pain Relevance 0.43
Although a 150 mg dose of aspirin reduced urinary dinor-TxB2 levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina").
Negative_regulation (reduced) of TxB2 associated with aspirin, angina and increased venous pressure under development
14) Confidence 0.00 Published 1981 Journal N. Engl. J. Med. Section Abstract Doc Link 7010173 Disease Relevance 0.79 Pain Relevance 0.53
Renal function, plasma renin activity (PRA) and urinary PGs were not affected during control collections, while all three NSAIDs decreased thromboxane B2 (TxB2).
Negative_regulation (decreased) of TxB2 in plasma associated with cinod
15) Confidence 0.00 Published 1985 Journal Kidney Int. Section Abstract Doc Link 3884880 Disease Relevance 0.08 Pain Relevance 0.52
After furosemide, all NSAIDs decreased fractional excretions of Na+ and Cl-, PRA, and TxB2 by equivalent degrees (P less than 0.05).
Negative_regulation (decreased) of TxB2 associated with cinod
16) Confidence 0.00 Published 1985 Journal Kidney Int. Section Abstract Doc Link 3884880 Disease Relevance 0.08 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox