INT11897

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Context Info
Confidence 0.13
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 7.85
Pain Relevance 12.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
platelet 6
plasma 4
PGE2 3
spinal 2
phagocytes 1
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1 99.78 Very High Very High Very High
cINOD 40 99.70 Very High Very High Very High
Paracetamol 6 99.70 Very High Very High Very High
Regional anesthesia 5 99.68 Very High Very High Very High
Inflammation 26 99.50 Very High Very High Very High
acular 19 99.32 Very High Very High Very High
beta blocker 8 98.86 Very High Very High Very High
Serotonin 12 98.60 Very High Very High Very High
Angina 10 98.36 Very High Very High Very High
lidocaine 10 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1 99.78 Very High Very High Very High
INFLAMMATION 39 99.50 Very High Very High Very High
Myocardial Infarction 7 99.32 Very High Very High Very High
Coronary Artery Disease 2 99.28 Very High Very High Very High
Cv General 3 Under Development 10 98.36 Very High Very High Very High
Rheumatoid Arthritis 40 98.24 Very High Very High Very High
Brain Hemorrhage 1 97.92 Very High Very High Very High
Cv Unclassified Under Development 2 97.12 Very High Very High Very High
Infection 4 97.04 Very High Very High Very High
Pressure And Volume Under Development 3 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In VO, even CS TxB2 is absent at rest, and rises less rapidly than in VA, even during pacing-induced ischemia.
Neg (absent) Gene_expression (absent) of TxB2 associated with angina and ischemia
1) Confidence 0.13 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 0.79 Pain Relevance 0.58
KT despite near complete abolition of TxB2 production.
Gene_expression (production) of TxB2 associated with acular
2) Confidence 0.09 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7598238 Disease Relevance 0.06 Pain Relevance 0.95
Plasma TxB2 and TxB2 production by platelets increased during both spinal and epidural anesthesia.
Gene_expression (production) of TxB2 in spinal associated with anesthesia and epidural
3) Confidence 0.08 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0 Pain Relevance 0.75
Plasma TxB2 and TxB2 production by platelets increased during both spinal and epidural anesthesia.
Gene_expression (production) of TxB2 in spinal associated with anesthesia and epidural
4) Confidence 0.08 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0 Pain Relevance 0.75
In in vitro studies, only low concentrations of lidocaine (0.5-1.0 micrograms/ml) and bupivacaine (0.5-3.0 micrograms/ml) increased platelet TxB2 production.
Gene_expression (production) of TxB2 in platelet associated with lidocaine
5) Confidence 0.07 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0 Pain Relevance 0.99
The results suggest that the increased TxB2 plasma levels and platelet TxB2 production during regional anesthesia are not caused by local anesthetics itself but by other factors, e.g. tissue trauma.
Gene_expression (production) of TxB2 in platelet associated with injury, regional anesthesia and local anesthetic
6) Confidence 0.06 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0.10 Pain Relevance 0.98
Moreover, orally applied latex beads appeared in Tx-mLN as well as Tx-pLN (Fig.
Gene_expression (appeared) of Tx-mLN
7) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0 Pain Relevance 0
The results suggest that the increased TxB2 plasma levels and platelet TxB2 production during regional anesthesia are not caused by local anesthetics itself but by other factors, e.g. tissue trauma.
Gene_expression (production) of TxB2 in platelet associated with injury, regional anesthesia and local anesthetic
8) Confidence 0.05 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2780766 Disease Relevance 0.10 Pain Relevance 0.99
Both NSAIDs inhibited the production of TxB2 to a similar extent.
Gene_expression (production) of TxB2 associated with cinod
9) Confidence 0.03 Published 1995 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 7674450 Disease Relevance 0.32 Pain Relevance 1.19
Thus blood sampling through long catheters across the coronary bed is both a reliable and necessary method for assessing intracoronary TxB2 production in patients with ischemic heart disease.
Gene_expression (production) of TxB2 in heart associated with coronary artery disease
10) Confidence 0.02 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 7102506 Disease Relevance 0.17 Pain Relevance 0
Loxoprofen sodium reduced the production of TxB2 and PGI2, and also reduced platelet aggregation in vivo.
Gene_expression (production) of TxB2 in platelet
11) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935154 Disease Relevance 0.78 Pain Relevance 0.21
mice (269.55 ± 77.48 ng/mg CRE vs 929.17 ± 196.29 ng/mg CRE, p = 0.012), and inhibited the production of urinary TxB2 by 26.2% compared to pre medication in men (0.53 ± 0.10 ng/mg CRE vs 2.04 ± 0.12 ng/mg CRE, p = 0.001) (Fig. 1A and D).
Gene_expression (production) of TxB2
12) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2935154 Disease Relevance 0.06 Pain Relevance 0
An original and easily reproducible technique for isolating and culturating mononucleated phagocytes from rheumatoid synovial fluid was used by the authors to study the synthesis of PGE2, PGF alpha 2 and TxB2 by macrophages taken from 16 patients with rheumatoid arthritis.
Gene_expression (synthesis) of TxB2 in phagocytes associated with rheumatoid arthritis
13) Confidence 0.01 Published 1982 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 7123126 Disease Relevance 0.21 Pain Relevance 0.05
SK&F 105809 inhibited LTB4 and PGE2 production in vivo in inflammatory exudates as well as the production of LTB4 and thromboxane B2 (TxB2) ex vivo in rat blood.
Gene_expression (production) of TxB2 in blood associated with inflammation
14) Confidence 0.01 Published 1990 Journal Drugs Exp Clin Res Section Abstract Doc Link 2127565 Disease Relevance 0.84 Pain Relevance 0.31
Plasma levels of 6-keto-PGF1 alpha and serotonin increased only to 131 and 149% of control at 50 min of infusion, and levels of PGF2 alpha and TxB2 decreased to 50 and 80% of control at 100 and 150 min of infusion, respectively.
Gene_expression (levels) of TxB2 in Plasma associated with serotonin
15) Confidence 0.00 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.15 Pain Relevance 0.30
Ibuprofen effectively suppressed endotoxin-induced increases in the plasma levels of TxB2, 6-keto-PGF1 alpha, PGF2 alpha, and serotonin and body temperature.
Gene_expression (levels) of TxB2 in body associated with serotonin
16) Confidence 0.00 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.15 Pain Relevance 0.26
Neither of the beta-blockers induced any change in the plasma concentration or serum production of TxB2.
Gene_expression (production) of TxB2 in plasma associated with beta blocker
17) Confidence 0.00 Published 1986 Journal Acta Neurol. Scand. Section Abstract Doc Link 3030039 Disease Relevance 0.27 Pain Relevance 0.43
Inhibition of platelet cyclooxygenase (COX 1) by aspirin is followed by relief of microvascular disturbances, correction of shortened platelet survival, and return of plasma levels of beta-tg, PF4, TM levels and TxB2 excretion to normal.
Gene_expression (levels) of TxB2 in plasma associated with aspirin and cox1
18) Confidence 0.00 Published 2006 Journal Platelets Section Abstract Doc Link 17127481 Disease Relevance 1.36 Pain Relevance 0.21
ADP-induced platelet aggregability, platelet cAMP, ATP and ADP levels, plasma cAMP and TxB2 concentration, as well as the serum production of TxB2 were measured before and after each treatment period.
Gene_expression (production) of TxB2 in platelet
19) Confidence 0.00 Published 1986 Journal Acta Neurol. Scand. Section Abstract Doc Link 3030039 Disease Relevance 0.31 Pain Relevance 0.48
Platelet TxB2 production decreased dramatically in the ketorolac group from preoperative to poststudy drug data points (157.2 +/- 129.4 to 0.3 +/- 0.3 ng/mL; P < 0.01).
Gene_expression (production) of TxB2 in Platelet associated with acular
20) Confidence 0.00 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8638787 Disease Relevance 0.15 Pain Relevance 1.25

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