INT118984

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 1.19
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Mc1r)
Anatomy Link Frequency
hair follicles 2
skin 2
melanocyte 1
Mc1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 10 91.04 High High
Cytomegalovirus Infection 5 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, this study verifies that ASP exerts its functions by acting as an independent ligand that downregulates the melanocyte MC1R and tyrosinase protein in an in vivo system.
Negative_regulation (downregulates) of MC1R in melanocyte associated with melanocortin 1 receptor
1) Confidence 0.53 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.19 Pain Relevance 0.25
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of MC1R in skin associated with melanocortin 1 receptor
2) Confidence 0.53 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.20
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of melanocortin-1 receptor in skin associated with melanocortin 1 receptor
3) Confidence 0.53 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.20
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of melanocortin-1 receptor in hair follicles associated with melanocortin 1 receptor
4) Confidence 0.18 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.20
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Negative_regulation (downregulation) of MC1R in hair follicles associated with melanocortin 1 receptor
5) Confidence 0.18 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.20

General Comments

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