INT118986

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.97
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (ASIP) signal transduction (ASIP) generation of precursor metabolites and energy (ASIP)
extracellular space (ASIP) extracellular region (ASIP) cell-cell signaling (ASIP)
Anatomy Link Frequency
skin 5
hair follicles 1
ASIP (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 12 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 8 92.04 High High
Cytomegalovirus Infection 4 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treated skin showed lighter skin colour after 3 days of ASP gene transfection.
Positive_regulation (transfection) of Gene_expression (transfection) of ASP gene in skin
1) Confidence 0.39 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.16
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Positive_regulation (transfection) of Gene_expression (transfection) of ASP gene in skin associated with melanocortin 1 receptor
2) Confidence 0.36 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.19
These observations demonstrate that gene transfer using the gene gun method can induce high cutaneous ASP production and facilitate a switch from dark to fair colour without systemic pleiotropic effects.
Positive_regulation (induce) of Gene_expression (production) of ASP
3) Confidence 0.31 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.22 Pain Relevance 0.25
Successful transfection of ASP gene in skin and hair follicles, as well as downregulation of melanocortin-1 receptor (MC1R) and tyrosinase expression upon treatment, was confirmed using immunohistochemistry and Western blot analysis.
Positive_regulation (transfection) of in hair follicles Gene_expression (transfection) of ASP gene in skin associated with melanocortin 1 receptor
4) Confidence 0.12 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.25 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox