INT1190

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 3
Speculated 7
Reported most in Abstract
Documents 53
Total Number 60
Disease Relevance 46.41
Pain Relevance 11.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
plasma 6
platelet 3
skin 2
thorax 1
hepatocytes 1
F2 (Rattus norvegicus)
F2 - G20210A (3)
Pain Link Frequency Relevance Heat
cva 132 100.00 Very High Very High Very High
cINOD 35 99.70 Very High Very High Very High
Angina 15 99.52 Very High Very High Very High
Pain 31 99.42 Very High Very High Very High
Paracetamol 17 98.94 Very High Very High Very High
headache 15 98.92 Very High Very High Very High
aspirin 28 98.48 Very High Very High Very High
Migraine 9 98.32 Very High Very High Very High
tramadol 4 98.16 Very High Very High Very High
abdominal pain 7 98.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thrombosis Related Under Development 65 100.00 Very High Very High Very High
Leukocytosis 4 100.00 Very High Very High Very High
Anaemia 3 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 20 99.96 Very High Very High Very High
Thrombocytopenia 12 99.96 Very High Very High Very High
Constipation 5 99.96 Very High Very High Very High
Pericardial Effusion 19 99.90 Very High Very High Very High
Leptospirosis 56 99.84 Very High Very High Very High
Pressure And Volume Under Development 41 99.84 Very High Very High Very High
Thrombosis 234 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their decreasing order of activity in enhancing the elevated prothrombin time was phenylbutazone, diflunisal, acetylsalicylic acid, ibuprofen, indomethacin, tolmetin sodium, and ketoprofen.
Positive_regulation (elevated) of prothrombin associated with aspirin
1) Confidence 0.70 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
At the 24-hr pretreatment time, only phenylbutazone significantly reduced the elevated prothrombin time.
Positive_regulation (elevated) of prothrombin
2) Confidence 0.70 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.46
When compared to the preoperative values, prothrombin times were significantly increased throughout the postoperative period.
Positive_regulation (increased) of prothrombin
3) Confidence 0.68 Published 2006 Journal Anaesth Intensive Care Section Abstract Doc Link 16913338 Disease Relevance 0 Pain Relevance 0.11
DATA SYNTHESIS: King's criteria (pH < 7.30 or prothrombin time of >100 secs plus creatinine of >300 micromol/L plus encephalopathy grade of > or =3) were evaluated in nine studies, pH < 7.30 in four, prothrombin time of >100 secs in three, prothrombin time of >100 secs plus creatinine of >300 micromol/L plus encephalopathy grade of > or =3 in three, creatinine of >300 micromol/L in two, and one each for increase in prothrombin time day 4, factor V of <10%, Acute Physiology and Chronic Health Evaluation (APACHE) II score of >15, and Gc-globulin of <100 mg/L.
Positive_regulation (increase) of prothrombin
4) Confidence 0.63 Published 2003 Journal Crit. Care Med. Section Body Doc Link 12545033 Disease Relevance 0.11 Pain Relevance 0
Nonactivated and activated prothrombin complex concentrates have been successful in controlling acute bleeding in patients with inhibitors and have been useful in the surgical setting.
Positive_regulation (activated) of prothrombin associated with hemorrhage
5) Confidence 0.50 Published 2006 Journal Semin. Hematol. Section Abstract Doc Link 16690372 Disease Relevance 0.41 Pain Relevance 0
With the exception of amfenac sodium, all the NSAIDs significantly enhanced the elevated prothrombin time when administered 18 hr after warfarin.
Positive_regulation (enhanced) of prothrombin associated with cinod
6) Confidence 0.50 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
Their decreasing order of activity in enhancing the elevated prothrombin time was phenylbutazone, diflunisal, acetylsalicylic acid, ibuprofen, indomethacin, tolmetin sodium, and ketoprofen.
Positive_regulation (elevated) of prothrombin associated with aspirin
7) Confidence 0.50 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
With the exception of amfenac sodium, all the NSAIDs significantly enhanced the elevated prothrombin time when administered 18 hr after warfarin.
Positive_regulation (elevated) of prothrombin associated with cinod
8) Confidence 0.50 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.47
[Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state].
Positive_regulation (carrying) of prothrombin associated with thrombosis
9) Confidence 0.49 Published 1999 Journal J Fr Ophtalmol Section Title Doc Link 10609175 Disease Relevance 0.82 Pain Relevance 0.11
The two patients were treated with an activated prothrombin complex concentrate (FEIBA; Immuno, Vienna, Austria).
Positive_regulation (activated) of prothrombin
10) Confidence 0.49 Published 1999 Journal Haemophilia Section Abstract Doc Link 10469185 Disease Relevance 0.48 Pain Relevance 0.12
Conditions such as congestive heart failure, malignancy, malnutrition, diarrhoea and unsuspected vitamin K deficiency, enhance the prothrombin time response.
Positive_regulation (enhance) of prothrombin in heart associated with appetite loss, malignant neoplastic disease, heart rate under development and diarrhoea
11) Confidence 0.49 Published 2000 Journal Drugs Aging Section Abstract Doc Link 10939307 Disease Relevance 1.10 Pain Relevance 0.24
In vitro the venom had a fibrinogen-converting activity, it did not activate purified prothrombin but very likely contained a F V and Ca2+-dependent prothrombin activator.
Neg (not) Positive_regulation (activate) of prothrombin
12) Confidence 0.49 Published 1998 Journal Toxicon Section Abstract Doc Link 9723832 Disease Relevance 1.29 Pain Relevance 0.20
The elevation of the 24-hr prothrombin time was indicative of the effect of the warfarin.
Positive_regulation (elevation) of prothrombin
13) Confidence 0.47 Published 1985 Journal Life Sci. Section Abstract Doc Link 3974406 Disease Relevance 0.07 Pain Relevance 0.35
We conclude that prothrombin F1.2 levels are elevated in a significant number of patients with migraine with aura but not in patients with migraine without aura.
Neg (not) Positive_regulation (elevated) of prothrombin associated with migraine
14) Confidence 0.43 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11422096 Disease Relevance 1.15 Pain Relevance 0.76
On completion of surgery, the prothrombin time was significantly increased (P < 0.05), and the partial thromboplastin time significantly decreased (P < 0.05) in all the patients (when compared to preoperative values); the clinical significance of this is unclear.
Positive_regulation (increased) of prothrombin
15) Confidence 0.28 Published 1998 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 10101549 Disease Relevance 0.95 Pain Relevance 0.20
Prolongation of the paracetamol half-life was related to reduced plasma albumin and increased prothrombin time.
Positive_regulation (increased) of prothrombin in plasma associated with paracetamol
16) Confidence 0.28 Published 1979 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 499292 Disease Relevance 0.49 Pain Relevance 0.76
Tumor cells can either directly activate the blood clotting system or indirectly stimulate mononuclear cells to synthesize and express various procoagulants, subsequently leading to prothrombin activation, fibrin formation, and generation of a thrombus.
Positive_regulation (activation) of prothrombin in mononuclear cells associated with coagulation disorder, cancer and thrombosis
17) Confidence 0.28 Published 1999 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 10357083 Disease Relevance 1.71 Pain Relevance 0.11
Changes in clinical pathology parameters included decreases in red blood cell count, hemoglobin, and hematocrit mean values; elevation in platelet counts; and an increase in prothrombin and activated partial thromboplastin times.
Spec (partial) Positive_regulation (increase) of prothrombin in platelet
18) Confidence 0.26 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812216 Disease Relevance 0.78 Pain Relevance 0.11
Laboratory values revealed critical elevations of prothrombin time and international normalized ratio.
Positive_regulation (elevations) of prothrombin
19) Confidence 0.24 Published 1998 Journal Pharmacotherapy Section Abstract Doc Link 9692666 Disease Relevance 0.10 Pain Relevance 0.34
Prothrombin time and bilirubin levels were normal or only slightly elevated.
Positive_regulation (elevated) of Prothrombin
20) Confidence 0.22 Published 1975 Journal South. Med. J. Section Abstract Doc Link 173024 Disease Relevance 0.71 Pain Relevance 0.09

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