INT119016

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.65
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD19)
Anatomy Link Frequency
B cell 2
CD19 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 90.12 High High
Inflammation 15 88.48 High High
headache 3 85.64 High High
cytokine 21 83.36 Quite High
rheumatoid arthritis 24 78.92 Quite High
dexamethasone 2 77.24 Quite High
backache 2 76.24 Quite High
chemokine 2 24.08 Low Low
methotrexate 13 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 76 99.56 Very High Very High Very High
Malaria 163 99.34 Very High Very High Very High
Herpes Simplex Encephalitis 3 99.00 Very High Very High Very High
Pancreatic Cancer 5 98.20 Very High Very High Very High
Liver Cancer 1 95.00 High High
Herpes Simplex Virus 3 94.44 High High
Cancer 4 92.92 High High
Recurrence 64 91.32 High High
INFLAMMATION 22 88.48 High High
Lymphopenia 2 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished.
Negative_regulation (diminished) of CD19
1) Confidence 0.37 Published 2004 Journal Acta Medica (Hradec Kralove) Section Abstract Doc Link 15168883 Disease Relevance 1.00 Pain Relevance 0.13
Serum carbohydrate antigen 19-9 (CA19-9) decreased from 122,000 U/ml to 10,200 U/ml.
Negative_regulation (decreased) of Serum carbohydrate antigen 19-9
2) Confidence 0.36 Published 2004 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 15508450 Disease Relevance 0.98 Pain Relevance 0.08
CD19 cell numbers declined after treatment with rituximab following a protocol proposed by Cree and co-workers (Cree et al., 2005).
Negative_regulation (numbers) of CD19
3) Confidence 0.34 Published 2008 Journal Brain Section Body Doc Link PMC2577801 Disease Relevance 0.24 Pain Relevance 0.04
Second, B cells may be depleted by monoclonal antibodies that inhibit CD19, CD20, CD21, or CD22 B cell surface antigen.
Negative_regulation (inhibit) of CD19 in B cell
4) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833972 Disease Relevance 0.35 Pain Relevance 0.23
During acute malaria infections, there is an overall decrease in total CD19+ peripheral B-cell populations, yet further delineation of B-cell subsets demonstrates a transient increase in the proportion of CD38+ IgD-memory B cells (41,42).
Negative_regulation (decrease) of CD19 in B-cell associated with malaria and infection
5) Confidence 0.18 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 1.08 Pain Relevance 0

General Comments

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