INT119017

Context Info Confidence 0.39 First Reported 2004 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.16 Pain Relevance 0.21

cell adhesion (CD22) plasma membrane (CD22)

Anatomy Link Frequency B cells 2 synovium 1 CD22 (Homo sapiens)

Pain Link Frequency Relevance Heat medulla 1 89.40 headache 3 84.92 rheumatoid arthritis 74 84.44 methotrexate 19 31.92 corticosteroid 16 5.00 Antihistamine 7 5.00 tolerance 6 5.00 cytokine 5 5.00 Paracetamol 5 5.00 cINOD 3 5.00

Disease Link Frequency Relevance Heat Autoimmune Disease 32 99.92 Lymphatic System Cancer 17 98.64 Herpes Simplex Encephalitis 3 98.28 Herpes Simplex Virus 3 93.72 Disease 53 90.84 Ataxia 1 86.12 Tinnitus 1 85.68 Vertigo 1 85.28 Headache 3 84.92 Fever 3 84.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blocking CD22 in vivo in different settings and involving different B-cell populations needs to be studied further in order to further elucidate the complex role of CD22 and various antagonistic antibodies in B-cell development and in B-cell diseases.

Negative_regulation (Blocking) of CD22 in B-cell associated with disease

1) Confidence 0.39 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.83 Pain Relevance 0

Studies in CD22-deficient mice and in CD22-negative cell lines have shown an increase in calcium response to BCR ligation [33-36], indicating that CD22 inhibition of BCR signaling is achieved through the mechanism of controlling calcium efflux in B cells.

Negative_regulation (inhibition) of CD22 in B cells

2) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.11 Pain Relevance 0

The latter is in line with the findings of a previous study showing incomplete depletion of CD22+ B-cells in synovium (Vos et al 2007).

Negative_regulation (depletion) of CD22 in synovium

3) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.22 Pain Relevance 0.08

CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished.

Negative_regulation (diminished) of CD22

4) Confidence 0.22 Published 2004 Journal Acta Medica (Hradec Kralove) Section Abstract Doc Link 15168883 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

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