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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.16
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD22) plasma membrane (CD22)
Anatomy Link Frequency
B cells 2
synovium 1
CD22 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 1 89.40 High High
headache 3 84.92 Quite High
rheumatoid arthritis 74 84.44 Quite High
methotrexate 19 31.92 Quite Low
corticosteroid 16 5.00 Very Low Very Low Very Low
Antihistamine 7 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Paracetamol 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 32 99.92 Very High Very High Very High
Lymphatic System Cancer 17 98.64 Very High Very High Very High
Herpes Simplex Encephalitis 3 98.28 Very High Very High Very High
Herpes Simplex Virus 3 93.72 High High
Disease 53 90.84 High High
Ataxia 1 86.12 High High
Tinnitus 1 85.68 High High
Vertigo 1 85.28 High High
Headache 3 84.92 Quite High
Fever 3 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking CD22 in vivo in different settings and involving different B-cell populations needs to be studied further in order to further elucidate the complex role of CD22 and various antagonistic antibodies in B-cell development and in B-cell diseases.

Negative_regulation (Blocking) of CD22 in B-cell associated with disease
1) Confidence 0.39 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.83 Pain Relevance 0
Studies in CD22-deficient mice and in CD22-negative cell lines have shown an increase in calcium response to BCR ligation [33-36], indicating that CD22 inhibition of BCR signaling is achieved through the mechanism of controlling calcium efflux in B cells.
Negative_regulation (inhibition) of CD22 in B cells
2) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.11 Pain Relevance 0
The latter is in line with the findings of a previous study showing incomplete depletion of CD22+ B-cells in synovium (Vos et al 2007).
Negative_regulation (depletion) of CD22 in synovium
3) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.22 Pain Relevance 0.08
CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished.
Negative_regulation (diminished) of CD22
4) Confidence 0.22 Published 2004 Journal Acta Medica (Hradec Kralove) Section Abstract Doc Link 15168883 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

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