INT119017
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Blocking CD22 in vivo in different settings and involving different B-cell populations needs to be studied further in order to further elucidate the complex role of CD22 and various antagonistic antibodies in B-cell development and in B-cell diseases.
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Studies in CD22-deficient mice and in CD22-negative cell lines have shown an increase in calcium response to BCR ligation [33-36], indicating that CD22 inhibition of BCR signaling is achieved through the mechanism of controlling calcium efflux in B cells. | |||||||||||||||
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The latter is in line with the findings of a previous study showing incomplete depletion of CD22+ B-cells in synovium (Vos et al 2007). | |||||||||||||||
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CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished. | |||||||||||||||
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General Comments
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