INT119018

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 12.44
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TREH) hydrolase activity, acting on glycosyl bonds (TREH) plasma membrane (TREH)
carbohydrate metabolic process (TREH)
Anatomy Link Frequency
embryonic stages 1
smooth muscle 1
TREH (Homo sapiens)
Pain Link Frequency Relevance Heat
conotoxin 3 100.00 Very High Very High Very High
Nav1.7 6 98.04 Very High Very High Very High
imagery 17 96.72 Very High Very High Very High
Glutamate receptor 1 94.32 High High
antagonist 1 92.80 High High
sodium channel 4 90.44 High High
nociceptor 40 89.96 High High
Pain 4 89.76 High High
Nicotine 2 89.64 High High
anesthesia 10 84.24 Quite High
Disease Link Frequency Relevance Heat
Adhesions 94 99.84 Very High Very High Very High
Reprotox - General 1 17 99.84 Very High Very High Very High
Targeted Disruption 527 99.80 Very High Very High Very High
Cancer 188 99.50 Very High Very High Very High
Metastasis 9 99.32 Very High Very High Very High
Disease 275 99.08 Very High Very High Very High
Death 50 90.64 High High
Motor Neuron Diseases 160 90.08 High High
Pain 4 89.76 High High
Injury 59 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C31 integrase may not have played a role in tumor formation in the LAP-tTA/TRE-MYC transgenic mouse model.


Gene_expression (/) of TRE associated with targeted disruption and cancer
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 1.01 Pain Relevance 0.09
Sox10+/rtTA neurospheres were transfected with the TREbi-Runx1-EYFP expression vector (Fig. 1D).
Gene_expression (transfected) of TRE
2) Confidence 0.65 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.08 Pain Relevance 0
Sox10+/rtTA neurospheres were transfected with the TREbi-Runx1-EYFP expression vector (Fig. 1D).
Gene_expression (expression) of TRE
3) Confidence 0.65 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.08 Pain Relevance 0
Differentiation of Sox10+/rtTA:TREBi-Runx1-EYFP bNCSCs In Vitro
Gene_expression (bNCSCs) of TRE
4) Confidence 0.65 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.09 Pain Relevance 0
For bromodeoxyuridine (BrdU) labeling, six mice with neurospheres harboring Sox10+/rtTA:TREbi-EYFP-Runx1 transgenes were injected with BrdU intraperitoneally once every day (10 mg/ml; 200 ?
Gene_expression (rtTA) of TRE
5) Confidence 0.65 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.12 Pain Relevance 0.03
Dumotiez then produced the first prototype of the bdellomètre in its various versions, agreeing that these instruments would be given to Dr Bernard.
Gene_expression (produced) of bdellom tre
6) Confidence 0.55 Published 2009 Journal Medical History Section Body Doc Link PMC2668889 Disease Relevance 0.11 Pain Relevance 0
In Van den Bosch's view, the author improved Sarlandière's bdellomètre, by comparison with the illustration published in Van Onsenoort's Operatieve Heelkunde.36
Gene_expression (improved) of bdellom tre
7) Confidence 0.48 Published 2009 Journal Medical History Section Body Doc Link PMC2668889 Disease Relevance 0 Pain Relevance 0
Initially, pressure of work kept Sarlandière from designing his bdellomètre, which he had envisaged several years earlier.
Gene_expression (designing) of bdellom tre
8) Confidence 0.48 Published 2009 Journal Medical History Section Body Doc Link PMC2668889 Disease Relevance 0.25 Pain Relevance 0.03
That same year his bdellomètre was shown at the Exposition de l'Industrie in the Louvre Museum.20

Operating the Bdellome`tre

Gene_expression (shown) of bdellom tre
9) Confidence 0.48 Published 2009 Journal Medical History Section Body Doc Link PMC2668889 Disease Relevance 0.29 Pain Relevance 0.09
It is concluded that VGSCalpha expression increases significantly in CaP in vivo and that Nav1.7 is a potential functional diagnostic marker.
Gene_expression (expression) of VGSCalpha associated with nav1.7 and reprotox - general 1
10) Confidence 0.06 Published 2005 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16088330 Disease Relevance 0.86 Pain Relevance 0.34
To investigate VGSCalpha expression in CaP in vivo, immunohistochemistry and real-time PCR were performed on human prostate biopsies (n>20).
Spec (investigate) Gene_expression (expression) of VGSCalpha associated with reprotox - general 1
11) Confidence 0.06 Published 2005 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16088330 Disease Relevance 0.77 Pain Relevance 0.31
When tumors had reached 7–8 mm in diameter, intratumoral injection of AAV-2/TRE/HSVtk/Tet-On (100 ?
Gene_expression (/) of TRE associated with cancer
12) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 0.72 Pain Relevance 0.08
When tumors had reached 7–8 mm in diameter, intratumoral injection of AAV-2/TRE/HSVtk/Tet-On (100 ?
Gene_expression (/) of TRE associated with cancer
13) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 0.71 Pain Relevance 0.08
To test whether the severe phenotype observed in the constitutive transgenic rats could be reproduced in conditional transgenic rats, we produced the TRE-TDP-43M337V and tTA double transgenic rats by crossing the TRE-TDP-43M337V transgenic lines with a tTA transgenic line that expresses the tTA transgene at levels sufficient to vigorously activate tTA reporter genes [24].
Gene_expression (produced) of TRE associated with targeted disruption
14) Confidence 0.04 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 1.01 Pain Relevance 0
Consistent with findings in constitutive transgenic rats (Figure 1), expression of the TRE-TDP-43M337V transgene from early embryonic stages caused severe phenotypes in the conditional transgenic rats of line 16 (Figure 2B).
Gene_expression (expression) of TRE in embryonic stages associated with targeted disruption
15) Confidence 0.04 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 1.13 Pain Relevance 0
What is the raison d'être of NRF?
Gene_expression (is) of raison d' tre
16) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.26 Pain Relevance 0.04
In the absence of Dox, tTA constantly activates the TRE-TDP-43M337V transgene, producing an expression pattern that is indistinguishable from constitutive transgene expression [24].
Gene_expression (expression) of TRE
17) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 0.95 Pain Relevance 0
The disease phenotypes observed in the mutant TDP (TRE-TDP-43M337V) transgenic rats were not observed in normal TDP transgenic rats (miniTDP-43WT) by an age of 200 days, though these rats expressed the human TDP transgene at comparable levels as TRE-TDP-43M337V rats (Figure 2B–2E).
Gene_expression (expressed) of TRE associated with targeted disruption and disease
18) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 1.96 Pain Relevance 0.03
To obtain a constitutive pattern of transgene expression, we allowed the TRE-TDP-43M337V transgene to be expressed from early embryogenesis by withholding Dox treatment.
Gene_expression (expressed) of TRE
19) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2845661 Disease Relevance 1.15 Pain Relevance 0
The separation of the rtTA2S-M2 and TRE expressing vectors might serve as a useful tool to specifically target certain cell types for expression of the desired key transcription factor.
Gene_expression (expressing) of TRE
20) Confidence 0.01 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.07 Pain Relevance 0.12

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