INT119025

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 31.32
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 12
cleavage 3
lower respiratory tract 1
colon 1
PNT2 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 9 99.98 Very High Very High Very High
sodium channel 3 99.92 Very High Very High Very High
corticosteroid 36 99.22 Very High Very High Very High
cINOD 37 98.66 Very High Very High Very High
Demyelination 9 97.04 Very High Very High Very High
Dismenorea 1 94.80 High High
depression 4 94.04 High High
imagery 21 89.20 High High
Multiple sclerosis 369 87.92 High High
Neurotransmitter 1 87.12 High High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 728 100.00 Very High Very High Very High
Infection 450 100.00 Very High Very High Very High
Thyroid Neoplasm 575 99.84 Very High Very High Very High
Reprotox - General 1 19 99.84 Very High Very High Very High
Cancer 618 99.66 Very High Very High Very High
Colon Cancer 13 99.60 Very High Very High Very High
Carcinoid 12 99.48 Very High Very High Very High
Breast Cancer 178 99.12 Very High Very High Very High
Lymphatic System Cancer 3 98.84 Very High Very High Very High
Renal Cancer 62 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, it was prevented by the inhibition of the proteolytic gamma-secretase enzyme or the transcription machinery, and was mimicked by the transfection of the intracellular domain of Notch.
Gene_expression (transfection) of Notch in Notch
1) Confidence 0.75 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.45 Pain Relevance 0.16
Notch1 and Notch2 were differentially expressed in PCa cell lines of varying metastatic potential (LNCaP, PC-3, PC-3M) in comparison to a normal prostate cell line (PNT2), whereas Notch3 and Notch4 were not expressed.
Gene_expression (expressed) of Notch1 in PNT2 associated with reprotox - general 1
2) Confidence 0.72 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.37 Pain Relevance 0.05
mediators have been joined by others including Notch/Delta, semaphorin, ephrin,
Gene_expression (others) of Notch in Notch
3) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.54 Pain Relevance 0.04
mediators have been joined by others including Notch/Delta, semaphorin, ephrin,
Gene_expression (/) of Notch in Notch
4) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.54 Pain Relevance 0.04
However, the effect of Tan-I on human colon cancer cells is not clearly understood yet.
Gene_expression (effect) of Tan-I in colon associated with colon cancer
5) Confidence 0.62 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18949381 Disease Relevance 0.94 Pain Relevance 0.09
In the present study, we found that Notch1 is not detectable in human GI carcinoid tumor cells.
Neg (not) Gene_expression (detectable) of Notch1 associated with carcinoid
6) Confidence 0.60 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.54 Pain Relevance 0
On the other hand, some nonsteroidal anti-inflammatory drugs, such as ibuprofen and sulindac, noncompetitively inhibited Abeta production but not Notch cleavage.
Gene_expression (production) of Notch in cleavage associated with inflammation, cinod and abeta
7) Confidence 0.58 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15170082 Disease Relevance 0.79 Pain Relevance 0.40
The Notch ligand Jagged1, but not Jagged2, was increased in all cell lines, whereas the Notch downstream target Deltex was not expressed.
Neg (not) Gene_expression (expressed) of Notch in Notch
8) Confidence 0.56 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.34 Pain Relevance 0.11
In contrast, the Notch ligand Delta-like1 (Dll1) levels were higher in LNCaP compared with PC-3 and PC-3M cells.
Gene_expression (levels) of Notch in PC-3
9) Confidence 0.56 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16832382 Disease Relevance 0.31 Pain Relevance 0.12
In many types of cancer, including pancreatic, colon, nonsmall cell lung cancer (NSCLC), cervical and renal cell cancer, Notch1 is upregulated; furthermore, it has been suggested that expression of Notch1 signaling prevents cellular differentiation and inhibits apoptosis in these cancer types.
Gene_expression (expression) of Notch1 in lung associated with non-small-cell lung cancer, cancer, renal cancer and apoptosis
10) Confidence 0.52 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.59 Pain Relevance 0
Overexpression of the Notch1 intracellular domain in MTC
Gene_expression (Overexpression) of Notch1 associated with thyroid neoplasm
11) Confidence 0.51 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.43 Pain Relevance 0
Using a doxycycline-inducible NICD in MTC cells (TT cells), we have recently shown that overexpression of Notch1 in MTC cells – Notch1 signaling is normally absent in MTC cells – results in a dose-dependent reduction in NE tumor markers and growth (Kunnimalaiyaan et al 2006, 2007a; Kunnimalaiyaan and Chen 2007).
Gene_expression (overexpression) of Notch1 associated with thyroid neoplasm and cancer
12) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.79 Pain Relevance 0
It has been suggested that expression of Notch1 signaling prevents cellular differentiation and inhibits apoptosis in certain cancers.
Gene_expression (expression) of Notch1 associated with cancer and apoptosis
13) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.87 Pain Relevance 0
The H5N1 viral loads in our patients were consistent with those (log10 cDNA 4.3–8.2) from another Vietnamese series.[5]
Gene_expression (loads) of H5N1
14) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.43 Pain Relevance 0.08
Detection of the 2009 Influenza A (H1N1)v Virus
Gene_expression (Detection) of H1N1 associated with influenza virus infection
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951908 Disease Relevance 0.56 Pain Relevance 0
833 fold the IC50 of her infecting H5N1 virus.
Gene_expression (virus) of H5N1
16) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.39 Pain Relevance 0.09
In vitro, mean IC50 OC values against H5N1 vary by viral clade and methodology, ranging from ?
Gene_expression (values) of H5N1
17) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.47 Pain Relevance 0
Using a human Stem Cell Gene Array, we found that the CD133+CXCR4+CD34- sorted cells expressed genes reflective of vascular progenitors, including CD31, FZD 2/3/4/7, CXCR4, LIFR, and Notch promoter 1 (data not shown).
Gene_expression (expressed) of Notch in Notch
18) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.39 Pain Relevance 0
These findings fit with the absence of dead mallards in wild bird die-offs from HPAIV (H5N1) in Europe and Asia in 2005 and 2006 (14,24,25), although HPAIV (H5N1) was detected in 1 dead mallard during the recent 2007 HPAI (H5N1) outbreak in wild birds in Germany (26).
Gene_expression (detected) of H5N1
19) Confidence 0.16 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2570914 Disease Relevance 0.23 Pain Relevance 0
As summarized in Table 4, the markers include several signaling proteins, some of them previously implicated in cancer transformation (Notch signaling, Wnt signaling, TGF-?
Gene_expression (signaling) of Notch in Notch associated with cancer
20) Confidence 0.12 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.03 Pain Relevance 0.03

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