INT119030

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (POMC, Ighg1) small molecule metabolic process (POMC) cell-cell signaling (POMC)
cytoplasm (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
macrophages 1
POMC (Homo sapiens)
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 4 97.18 Very High Very High Very High
narcan 1 91.88 High High
Enkephalin 1 91.12 High High
agonist 1 81.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The non-opioid beta-endorphin receptor of macrophages has in addition to immunorphine (Kd of the [3H]immunorphine-receptor complex was 2.4 +/- 0.1 nM) and beta-endorphin (Ki of the [3H]immunorphine specific binding was 2.9 +/- 0.2 nM) a high affinity for Fc-fragment of human IgG1, pentarphine (VKGFY), cyclopentarphine [cyclo(VKGFY)], and [Pro3]pentarphine (VKPFY) (Ki values were 0.0060 +/- 0.0004, 2.7 +/- 0.2, 2.6 +/- 0.2, and 2.8 +/- 0.2 nM, respectively) and is insensitive to naloxone and [Met5]enkephalin (Ki > 100 microM).
beta-endorphin Binding (affinity) of IgG1 in macrophages associated with narcan, enkephalin and opioid
1) Confidence 0.06 Published 2004 Journal Biochemistry Mosc. Section Abstract Doc Link 15170374 Disease Relevance 0 Pain Relevance 0.52

General Comments

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