INT119048

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 9.23
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.26 Very High Very High Very High
cINOD 3 99.00 Very High Very High Very High
Osteoarthritis 3 98.48 Very High Very High Very High
palliative 3 98.44 Very High Very High Very High
rheumatoid arthritis 68 97.72 Very High Very High Very High
Inflammatory response 5 91.88 High High
Inflammation 80 90.96 High High
Opioid 1 82.04 Quite High
agonist 92 50.00 Quite Low
cytokine 20 42.28 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 141 100.00 Very High Very High Very High
Stomach Cancer 4 99.88 Very High Very High Very High
Cancer 449 99.08 Very High Very High Very High
INFLAMMATION 82 98.88 Very High Very High Very High
Osteoarthritis 3 98.48 Very High Very High Very High
Pancreatic Cancer 82 97.84 Very High Very High Very High
Rheumatoid Arthritis 68 97.72 Very High Very High Very High
Esophageal Cancer 6 96.72 Very High Very High Very High
Ulcers 1 93.52 High High
Atherosclerosis 7 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-steroidal anti-inflammatory drugs, shown to reduce the risk of gastric cancer, can decrease HIF-1alpha expression.
Negative_regulation (decrease) of Gene_expression (expression) of HIF-1alpha associated with inflammation, cinod and stomach cancer
1) Confidence 0.57 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.37 Pain Relevance 0.10
Morphine treatment resulted in a significant decrease in the expression and nuclear translocation of HIF-1 alpha with a concurrent suppression in vascular endothelial growth factor (VEGF) synthesis.
Negative_regulation (decrease) of Gene_expression (expression) of HIF-1 alpha associated with morphine
2) Confidence 0.42 Published 2010 Journal Cell. Immunol. Section Abstract Doc Link 20843508 Disease Relevance 0.57 Pain Relevance 0.73
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Negative_regulation (evaluation) of Gene_expression (expression) of HIF-1 associated with esophageal cancer
3) Confidence 0.41 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.69 Pain Relevance 0.10
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Negative_regulation (evaluation) of Gene_expression (expression) of HIF-1 associated with esophageal cancer
4) Confidence 0.41 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.92 Pain Relevance 0
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Negative_regulation (decreased) of Gene_expression (expression) of HIF1a
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.77 Pain Relevance 0
Akakura et al have reported expression of HIF-1?
Negative_regulation (reported) of Gene_expression (expression) of HIF-1
6) Confidence 0.22 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.46 Pain Relevance 0
Inhibition of Stat3 activation blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo [151].
Negative_regulation (Inhibition) of Gene_expression (expression) of HIF-1 associated with cancer
7) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.79 Pain Relevance 0.07
Inhibition of Stat3 activation blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo [151].
Negative_regulation (blocks) of Gene_expression (expression) of HIF-1 associated with cancer
8) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.79 Pain Relevance 0.07
The decrease in EPC recruitment in the elderly may be associated with downregulation of tissue hypoxia-inducible factor 1 or insufficient local expression of VEGF, one of the key attractors of EPCs [14].
Negative_regulation (downregulation) of Gene_expression (expression) of tissue hypoxia-inducible factor 1 associated with hypoxia
9) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.57 Pain Relevance 0
The synovial expression of HIF-1?
Negative_regulation (synovial) of Gene_expression (expression) of HIF-1
10) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.28 Pain Relevance 0.42

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