INT119049

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TCEAL1)
TCEAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 98.44 Very High Very High Very High
agonist 33 88.64 High High
Inflammation 7 44.44 Quite Low
cINOD 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Cancer 6 96.28 Very High Very High Very High
Cancer 54 95.52 Very High Very High Very High
Hypoxia 10 95.28 Very High Very High Very High
Apoptosis 28 91.84 High High
Pancreatic Cancer 1 86.48 High High
Bladder Cancer 1 84.72 Quite High
Diabetes Mellitus 6 80.36 Quite High
Hyperplasia 3 73.32 Quite High
Death 4 72.24 Quite High
Liver Cancer 2 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Negative_regulation (evaluation) of p21 associated with esophageal cancer
1) Confidence 0.15 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.69 Pain Relevance 0.10
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Negative_regulation (evaluation) of p21 associated with esophageal cancer
2) Confidence 0.15 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.87 Pain Relevance 0
upregulates the CDK inhibitors p18 and p21 [162].
Negative_regulation (inhibitors) of p21
3) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.73 Pain Relevance 0.18

General Comments

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