INT119053

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.51
Pain Relevance 4.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A3) cell death (SLC6A3) aging (SLC6A3)
plasma membrane (SLC6A3) transmembrane transport (SLC6A3) cytoplasm (SLC6A3)
Anatomy Link Frequency
putamen 2
brain 2
erythrocyte 1
tail 1
striatum 1
SLC6A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 616 100.00 Very High Very High Very High
isoflurane 7 99.98 Very High Very High Very High
antagonist 6 99.80 Very High Very High Very High
monoamine 21 98.80 Very High Very High Very High
positron emission tomography 162 95.32 Very High Very High Very High
cocaine 42 95.28 Very High Very High Very High
anesthesia 3 87.16 High High
Thalamus 35 85.16 High High
imagery 135 83.08 Quite High
Neurotransmitter 58 82.04 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 282 99.68 Very High Very High Very High
Targeted Disruption 2 99.64 Very High Very High Very High
Parkinson's Disease 14 98.72 Very High Very High Very High
Disease 214 98.58 Very High Very High Very High
Hemolytic Anemia 13 95.68 Very High Very High Very High
Cognitive Disorder 48 93.08 High High
Hemolysis 24 93.00 High High
Parkinsonian Disorders 78 78.08 Quite High
Nicotine Addiction 349 70.80 Quite High
Drug Dependence 9 70.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the association of ADHD in humans with elevated DAT1 levels, knockout mice that have no DAT1 gene are also very hyperactive [55].
Positive_regulation (elevated) of DAT1 associated with targeted disruption and attention deficit hyperactivity disorder
1) Confidence 0.65 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.52 Pain Relevance 0.29
Also, increased DAT in caudate was associated with less deactivation in precuneus with increasing attentional load.
Positive_regulation (increased) of DAT
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.08 Pain Relevance 0.24
Chen et al. (2006) have shown that an acute dose of Mn produces a transient increase in DAT levels in the nonhuman primate striatum.
Positive_regulation (increase) of DAT in striatum
3) Confidence 0.52 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.36 Pain Relevance 0.26
Estradiol treatment increased the dopamine transporter in subregions of the intact caudate and putamen compared with the intact striata of vehicle-treated monkeys, but not in the lesioned striata.
Neg (not) Positive_regulation (increased) of dopamine transporter in putamen associated with dopamine
4) Confidence 0.46 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115413 Disease Relevance 0.28 Pain Relevance 0.41
Isoflurane induces dopamine transporter trafficking into the cell cytoplasm.
Positive_regulation (induces) of dopamine transporter associated with dopamine and isoflurane
5) Confidence 0.44 Published 2004 Journal Synapse Section Title Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.50
Increased DAT availability in striatum, which would result in lower DA in the synapse, was associated with lower deactivation of the precuneus (BA 7) and higher deactivation of the ventral ACG (BA 24/32).
Positive_regulation (Increased) of DAT in synapse associated with dopamine
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.07 Pain Relevance 0.25
Independent analyses were conducted for DAT measures in caudate and putamen.
Positive_regulation (conducted) of DAT in putamen
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.09 Pain Relevance 0.12
Specifically, we hypothesized that BOLD signals would be positively correlated with DAT (the lower the DAT the lower the activation in task specific regions and the higher the deactivation in the DMN).
Positive_regulation (activation) of DAT
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22
Specifically, we hypothesized that BOLD signals would be positively correlated with DAT (the lower the DAT the lower the activation in task specific regions and the higher the deactivation in the DMN).
Positive_regulation (activation) of DAT
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22
To ensure that one is selectively measuring DAT, an antagonist for the other monoaminergic uptake sites should be included in the assay.
Positive_regulation (measuring) of DAT associated with antagonist and monoamine
10) Confidence 0.33 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.29
The A1 allele has been correlated with a reduced number of dopamine binding sites in the brain [84,88-90], and with increased dopamine transporter levels [91].
Positive_regulation (increased) of dopamine transporter in brain associated with dopamine
11) Confidence 0.29 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.14 Pain Relevance 0.43
The A1 allele has been correlated with a reduced number of dopamine binding sites in the brain [84,88-90], and with increased dopamine transporter levels [91].
Positive_regulation (increased) of dopamine transporter in brain associated with dopamine
12) Confidence 0.29 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.14 Pain Relevance 0.43
Their patient's DAT was positive for anti-C3 and negative for anti-IgG, which suggests the formation of an antibody against the erythrocyte-drug complex.
Positive_regulation (positive) of DAT in erythrocyte
13) Confidence 0.20 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546413 Disease Relevance 0.46 Pain Relevance 0
In addition, from our work in the pituitary field, and the work of others, we know that multiple estrogens induce activation of MAPKs.129,130 The estrogenic activation of other kinases likely to act on DAT’s N-terminal tail have yet to be investigated;93,131 these include PKA, PKG, the subtypes of PKC (?
Spec (likely) Positive_regulation (activation) of DAT in tail
14) Confidence 0.13 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.14
Sprouting of remaining dopaminergic fibres after neurotoxic challenge has been reported in 6-OHDA lesion models of PD, and changes in presynaptic terminals, upregulation of AADC levels to increase dopamine conversions and reduced dopamine transporter have been demonstrated both in MPTP primate models and PD patients.
Positive_regulation (increase) of dopamine transporter associated with parkinson's disease, dopamine and disease
15) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.37 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox