| The exclusion criteria for randomisation were:
For the placebo controlled components: oral or transdermal HRT use in the last six months, ever use of HRT implant in women with a uterus, HRT implant inserted in last eight months in women with a hysterectomy.
History of endometriosis (hysterectomised or non-hysterectomised woman) or endometrial hyperplasia in a woman with a uterus.
History of invasive breast cancer, lobular carcinoma in-situ (LCIS), ductal carcinoma in-situ (DCIS), Paget's disease of the nipple or atypical hyperplasia of the breast.
Known BRCA1 or BRCA2 mutation carrier.
History of melanoma.
Invasive cancer at any other site apart from basal and squamous cell skin cancer within the last 10 years.
History of meningioma.
Myocardial infarction, cerebrovascular accident, sub-arachnoid haemorrhage or transient ischaemic attack within the last six months.
History of currently active liver disease or chronic liver disease but excluding Hepatitis A unless currently active.
Evidence of severe current renal impairment.
History of gall bladder disease in a woman who had not had a cholecystectomy or of gallstones following a cholecystectomy.
History of deep vein thrombosis, pulmonary embolism or retinal vein occlusion.
Positive thrombophilia screen (Factor V Leiden or prothrombin mutations, Protein C, Protein S or anti-thrombin III deficiencies, APC resistance, dysfibrinogenaemia or antiphospholipid antibodies).
History of hepatitis B, hepatitis C or HIV (not an exclusion in New Zealand).
Currently taking or has taken contraceptive drugs in the last 12 months.
Current triglyceride level (fasting) > 5.5 mmol/l.
Active participant in any other intervention trial likely to affect trial outcomes.
Taking tamoxifen, toremifene, raloxifene or any other selective oestrogen receptor modulator (SERM).
Other conditions/circumstances where the general practitioner judged that it would not be possible to obtain fully informed consent and/or successfully complete trial procedures.
| Negative_regulation (Known) of BRCA1 associated with porphyria, endometriosis (extended), cv general 4 under development, skin cancer, hyperplasia, liver disease, endometriosis, conductive hearing loss, hepatitis, brain tumor, lobular carcinoma, thrombophilia, gallbladder disease, gallstones, hepatitis a virus infection, disease, retinal vein occlusion, thrombosis, pulmonary embolism, ductal carcinoma, transdermal, cancer, basal and squamous cell skin cancer, acquired immune deficiency syndrome or hiv infection, noninfiltrating intraductal carcinoma, cva, reprotox - general 1 and myocardial infarction