INT119063

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 32
Disease Relevance 30.04
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA1) chromosome segregation (BRCA1) intracellular (BRCA1)
enzyme binding (BRCA1) DNA binding (BRCA1) protein complex (BRCA1)
Anatomy Link Frequency
blood 2
tubercle 2
poly 1
germline 1
sweats 1
BRCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 352 99.98 Very High Very High Very High
tolerance 52 99.86 Very High Very High Very High
fibrosis 9 99.40 Very High Very High Very High
abdominal pain 24 98.76 Very High Very High Very High
chemokine 16 97.28 Very High Very High Very High
Inflammation 415 96.64 Very High Very High Very High
cva 8 94.24 High High
Central nervous system 144 93.28 High High
headache 22 92.84 High High
Inflammatory response 64 90.12 High High
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 2160 100.00 Very High Very High Very High
Cryptococcal Meningitis 816 100.00 Very High Very High Very High
Ovarian Cancer 155 100.00 Very High Very High Very High
Pancreatic Cancer 52 99.84 Very High Very High Very High
Convulsion 16 99.76 Very High Very High Very High
Cystic Fibrosis 1 99.68 Very High Very High Very High
Breast Cancer 222 99.66 Very High Very High Very High
Fever 16 99.60 Very High Very High Very High
Pneumonia 34 99.56 Very High Very High Very High
Death 166 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative analysis of BRCA1 protein expression demonstrated regular staining in 50% of tumor specimens tested and reduced staining in 50% of tumor specimens tested.
Gene_expression (expression) of BRCA1
1) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15173085 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Our data demonstrate alteration of BRCA1 expression in chronic pancreatitis and sporadic pancreatic adenocarcinoma.
Gene_expression (expression) of BRCA1
2) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15173085 Disease Relevance 0.05 Pain Relevance 0
RESULTS: BRCA1 expression was down-regulated in chronic alcoholic pancreatitis, in particular on the RNA level.
Gene_expression (expression) of BRCA1
3) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15173085 Disease Relevance 0.08 Pain Relevance 0
Furthermore, our data indicate suppressed BRCA1 expression in pancreatic cancer on both the RNA and protein levels.
Gene_expression (expression) of BRCA1
4) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15173085 Disease Relevance 0.08 Pain Relevance 0
Similarly, correlation between PTCH1 alterations with BRCA1 deletion in group-A suggested its association with other DNA repair pathways.
Gene_expression (deletion) of BRCA1
5) Confidence 0.65 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.39 Pain Relevance 0
Similarly, BRCA dysfunction sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitors, leading to chromosomal instability, cell cycle arrest, and apoptosis in BRCA1 and BRCA2 deficient cells [36].
Gene_expression (dysfunction) of BRCA in poly associated with chromosomal instability and apoptosis
6) Confidence 0.65 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.66 Pain Relevance 0
In the last decade, the advancement of molecular biology improved the understanding of the pathogenesis of pancreatic cancer and characterized a number of genes that mutated in pancreatic cancers, such as somatic mutations in genes INK4A(CDKN2A), TP53, DPC4, BRCA1/2, STK11, APC, KRAS and ATM and PALB2 are found in pancreatic cancers [10]–[18].
Gene_expression (found) of BRCA1 associated with pancreatic cancer
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912284 Disease Relevance 1.37 Pain Relevance 0.07
This approach was successfully applied in linkage studies of families to map the causal mutation for many mono-genetic diseases, and sets of several hundreds of genome-wide VNTR markers were sufficient to identify loci such as the BRCA1 locus or the cystic fibrosis gene locus.
Gene_expression (locus) of BRCA1 associated with fibrosis, cystic fibrosis and disease
8) Confidence 0.65 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.27 Pain Relevance 0.05
Also, the presence of a breast cancer 1, early onset (BRCA1) germline mutation and expression of the human epidermal growth factor receptor 2 (Her2/neu) proto-oncogene seem to contribute to an increased rate of development of CNS metastases.
Gene_expression (expression) of BRCA1 in germline associated with breast cancer and metastasis
9) Confidence 0.56 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17579499 Disease Relevance 0.86 Pain Relevance 0
EXPERIMENTAL DESIGN: To study a potential correlation of BRCA1 and BRCA2 to chronic pancreatitis and development of sporadic pancreatic adenocarcinoma, we have analyzed the expression of these genes by quantitative PCR and performed immunohistochemical analyses in normal pancreatic tissues, chronic pancreatitis, and pancreatic cancer specimens.
Spec (analyzed) Gene_expression (expression) of BRCA1
10) Confidence 0.52 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15173085 Disease Relevance 0.09 Pain Relevance 0
Example: 'Low expression of BRCA1 was associated with colorectal cancer.'

• Genetic variation: A sentence states that a mutational event is reported to be related to a disease.

Gene_expression (expression) of BRCA1 associated with colon cancer and disease
11) Confidence 0.52 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2386138 Disease Relevance 0.82 Pain Relevance 0
Early onset drug use commenced for most of those interviewed during adolescence or early adulthood as a consequence of recreational use, experimentation, escape or part of the ‘hippie era’, or was triggered by child abuse and/or a parent dying, as this typical quote indicates:

‘Late onset’ problematic use of illicit drugs began later in the life course for some due to stressful life events such as divorce or death, or because of close personal relationships with a ‘drug user’, evidenced by this man talking about his partner:

Gene_expression (problematic) of Late onset associated with death
12) Confidence 0.48 Published 2010 Journal Journal of Advanced Nursing Section Body Doc Link PMC2984546 Disease Relevance 0.17 Pain Relevance 0.08
In order to achieve a PPV of 10% for detecting serous EOC among BRCA1 mutation carriers, a test must achieve a specificity requirement of 78.1% at 80% sensitivity given the incidence of serous ovarian cancer over age 50 in this population is approximately 3000 cases per 100,000 [6].
Gene_expression (detecting) of BRCA1 associated with ovarian cancer
13) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.78 Pain Relevance 0.04
Until then, the trends observed in our report may be useful to clinicians currently managing patients with MAC IRIS.
Gene_expression (managing) of IRIS associated with immune reconstitution inflammatory syndrome
14) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.92 Pain Relevance 0
Presenting symptoms of IRIS included fever (15 patients), abdominal pain (9), symptomatic lymphadenopathy (6), night sweats (4), loose stools (4), nausea and vomiting (4), fatigue, weight loss, and rash (1 each).
Gene_expression (Presenting) of IRIS in sweats associated with hot flashes, abdominal pain, lymphadenopathy, vomiting, fever, exanthema, immune reconstitution inflammatory syndrome, weight loss and fatigue
15) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 1.64 Pain Relevance 0.13
There was no major difference in viral load responses between the 2 groups at the time of IRIS diagnosis or IRIS follow up (Table 3).
Gene_expression (diagnosis) of IRIS associated with immune reconstitution inflammatory syndrome
16) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 1.12 Pain Relevance 0.11
There was no major difference in viral load responses between the 2 groups at the time of IRIS diagnosis or IRIS follow up (Table 3).
Gene_expression (diagnosis) of IRIS associated with immune reconstitution inflammatory syndrome
17) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 1.12 Pain Relevance 0.14
Subjects that do not progress to develop IRIS (IRIS tolerant) despite HAART initiation could develop either tolerance (anergy) to persistently existing LPS and tubercle antigens.
Gene_expression (tolerant) of IRIS in tubercle associated with immune reconstitution inflammatory syndrome and tolerance
18) Confidence 0.33 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.24 Pain Relevance 0.42
The likelihood of 'normal' FOXP3+ gene and endotoxin-tolerance among IRIS non-developers – Why?
Gene_expression (non) of IRIS associated with immune reconstitution inflammatory syndrome and tolerance
19) Confidence 0.33 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.90 Pain Relevance 0.30
We hypothesize that the excessive presence of LPS in HIV/TB coinfected subjects accounts for the progression of IRIS and those that have LPS in limited concentrations may not.
Gene_expression (progression) of IRIS associated with mycobacterial infection, immune reconstitution inflammatory syndrome and acquired immune deficiency syndrome or hiv infection
20) Confidence 0.33 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.17 Pain Relevance 0.30

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