INT119070

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOS1) signal transduction (SOS1) intracellular (SOS1)
DNA binding (SOS1)
SOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 85.84 High High
Inflammation 30 57.84 Quite High
cytokine 9 56.80 Quite High
aspirin 3 50.00 Quite Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
spondylitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 85.84 High High
Metabolic Syndrome 114 80.88 Quite High
Diabetes Mellitus 26 80.00 Quite High
Insulin Resistance 36 78.16 Quite High
Syndrome 12 59.96 Quite High
Cancer 3 51.92 Quite High
Necrosis 3 51.44 Quite High
Coronary Heart Disease 6 50.88 Quite High
Rheumatic Diseases 6 50.00 Quite Low
Abdominal Obesity 3 15.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the MAP kinase pathway begins with phosphorylation of Shc, Grb2/Sos and ras and results in the activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2.
Phosphorylation (phosphorylation) of Sos
1) Confidence 0.79 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 0.94 Pain Relevance 0.15
This was accompanied by a decrease in the expressions of SOS and phosphorylated MAP kinases, ERK1 and ERK2, but not FAK or Grab2.
Neg (not) Phosphorylation (phosphorylated) of SOS
2) Confidence 0.15 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0

General Comments

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