INT119076

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
Anatomy Link Frequency
coronary artery 1
fibroblasts 1
PEPD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 93.56 High High
aspirin 6 86.80 High High
fibrosis 4 46.16 Quite Low
ischemia 2 18.32 Low Low
Angina 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 22 100.00 Very High Very High Very High
Coronary Artery Disease 2 98.80 Very High Very High Very High
Hypertension 4 95.92 Very High Very High Very High
Stress 12 93.24 High High
INFLAMMATION 3 93.00 High High
Vascular Disease 2 90.24 High High
Prolidase Deficiency 3 89.64 High High
Fibrosis 7 81.90 Quite High
Increased Venous Pressure Under Development 4 37.84 Quite Low
Cv Unclassified Under Development 2 18.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibroblasts, prolidase activity is stimulated through a signal induced by an activated b1-integrin receptor that contributes to an increase in enzyme phosphorylation.
Positive_regulation (stimulated) of prolidase in fibroblasts
1) Confidence 0.63 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.09 Pain Relevance 0.26
The relationship between collagen and prolidase activity was observed during fibrotic processes, where an increase in prolidase activity was accompanied by increase in tissue collagen deposition.27 The negative effect of free radicals is mediated by degradative agents such as proteolytic enzymes and the last step of collagen degradation is mediated by prolidase.12 Surazynski et al. pointed out that prolidase may also have a role in angiogenesis as prolidase deficiency is associated with angiopathy.13 Oxidative stress resulted in collagen degradation and this process is mediated by prolidase.12 Moreover the degree of severity of oxidative stress is directly related to the inhibition of collagen production, and prolidase is thought to be the target enzyme of this process.28 Yildiz et al. showed that increased serum prolidase activity was significantly associated with the presence and severity of coronary artery disease.29 In accordance with their study we have shown that serum prolidase activity is significantly associated with the presence and severity of vasculogenic ED, and elevated serum prolidase activity may be an independent predictor of ED.10 In addition, it was suggested that hypertension and its duration is associated with increased serum prolidase activity and might be useful as a marker for the follow?
Positive_regulation (elevated) of prolidase in coronary artery associated with stress, fibrosis, prolidase deficiency, coronary artery disease, erectile dysfunction, vascular disease and hypertension
2) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 0.97 Pain Relevance 0
The mechanism of their action on collagen biosynthesis involves inactivation of prolidase, the enzyme that recovers proline from collagen degradation products for collagen re-synthesis.
Positive_regulation (inactivation) of prolidase
3) Confidence 0.46 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.09 Pain Relevance 0.26

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