INT119089

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 3.10
Pain Relevance 12.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 18
dorsal horn 4
interneurons 3
spinal cord 2
neuronal 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 188 100.00 Very High Very High Very High
Spinal nerve ligature 114 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
nMDA receptor 48 100.00 Very High Very High Very High
Kinase C 22 100.00 Very High Very High Very High
qutenza 22 100.00 Very High Very High Very High
nociceptor 10 100.00 Very High Very High Very High
analgesia 23 99.92 Very High Very High Very High
Neuropathic pain 104 99.88 Very High Very High Very High
Dorsal horn 19 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 186 99.88 Very High Very High Very High
Frailty 10 99.82 Very High Very High Very High
Injury 26 99.32 Very High Very High Very High
Pain 53 97.84 Very High Very High Very High
Nervous System Injury 10 94.96 High High
Targeted Disruption 2 92.64 High High
Hyperalgesia 46 91.04 High High
Nociception 17 88.80 High High
Sleep Disorders 6 74.64 Quite High
Tendon Injuries 11 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Spec (investigated) Regulation (role) of Phosphorylation (phosphorylation) of NR1 in spinal associated with nmda receptor and electroacupuncture
1) Confidence 0.61 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in rats.
Regulation (Effect) of Phosphorylation (phosphorylation) of NR1 in dorsal horn associated with spinothalamic tract, kinase c, qutenza and dorsal horn
2) Confidence 0.61 Published 2004 Journal Brain Res. Section Title Doc Link 15312791 Disease Relevance 0 Pain Relevance 1.39
The present study investigates the role of serine/threonine protein phosphatase 2A (PP2A) in the modulation of the phosphorylation of the NR1 and NR2B subunits of NMDA receptors in the spinal cord of rats following intradermal injection of capsaicin.
Spec (investigates) Regulation (modulation) of Phosphorylation (phosphorylation) of NR1 in spinal cord associated with qutenza, nmda receptor and spinal cord
3) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.54
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Regulation (modulating) of Phosphorylation (phosphorylation) of N-methyl-d-aspartate receptor in spinal associated with electroacupuncture
4) Confidence 0.45 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.43
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Regulation (modulating) of Phosphorylation (phosphorylation) of NMDAR in spinal associated with electroacupuncture
5) Confidence 0.45 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.44
This study examined the role of the intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid (BAPTA), in modulating the phosphorylation of the spinal N-methyl-d-aspartate receptor (NMDAR) NR1 and NR2B subunits after 2Hz electroacupuncture (EA) in rats.
Regulation (modulating) of Phosphorylation (phosphorylation) of NR1 in spinal associated with electroacupuncture
6) Confidence 0.45 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.44
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Regulation (modulation) of Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor in spinal associated with nmda receptor and electroacupuncture
7) Confidence 0.45 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Regulation (modulation) of Phosphorylation (phosphorylation) of NMDAR in spinal associated with nmda receptor and electroacupuncture
8) Confidence 0.45 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
Furthermore, these findings suggest that the modulation of spinal NR1 phosphorylation is linked to the effect of IT clonidine on postsynaptic neuronal activity.


Regulation (modulation) of Phosphorylation (phosphorylation) of NR1 in neuronal
9) Confidence 0.45 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20007733 Disease Relevance 0 Pain Relevance 0
Previous study suggests that ketamine combined with methamphetamine could down-regulate NR1 receptor phosphorylation in rats (phosphorylation site: serine 897) [29].
Regulation (regulate) of Phosphorylation (phosphorylation) of NR1 receptor associated with ketamine
10) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.88 Pain Relevance 1.65
In conclusion, intracellular calcium may play an important role in low-frequency EA analgesia by modulating the phosphorylation state of the spinal NMDAR subunits.
Regulation (modulating) of Phosphorylation (phosphorylation) of NMDAR in spinal associated with electroacupuncture and analgesia
11) Confidence 0.39 Published 2010 Journal Acta Histochem. Section Abstract Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.52
Effects of ketamine on SNL-induced NMDAR phosphorylation
Regulation (Effects) of Phosphorylation (phosphorylation) of NMDAR associated with ketamine and spinal nerve ligature
12) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.19 Pain Relevance 0.95
The present study investigated the role of inhibitor of protein phosphatases 1 and 2A on the modulation of the phosphorylation of the spinal N-methyl-D-aspartate receptor (NMDAR) NR1 and NR2B subunits following electroacupuncture (EA) stimulation in rats.
Regulation (modulation) of Phosphorylation (phosphorylation) of NR1 in spinal associated with nmda receptor and electroacupuncture
13) Confidence 0.27 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.63
These results demonstrate the distinct expression of phospho-NR1 subunits in different populations of striatal projection neurons and interneurons at variable levels in normal rats; they also demonstrate that phosphorylation of NR1, at least on serine 896 and 890 sites, is sensitive to drug exposure.
Regulation (sensitive) of Phosphorylation (phosphorylation) of NR1 in interneurons associated with projection neuron
14) Confidence 0.27 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15174082 Disease Relevance 0 Pain Relevance 0.52
Involvement of intracellular calcium on the phosphorylation of spinal N-methyl-D-aspartate receptor following electroacupuncture stimulation in rats.
Regulation (Involvement) of Phosphorylation (phosphorylation) of N-methyl-D-aspartate receptor in spinal associated with pain, nmda receptor and electroacupuncture
15) Confidence 0.24 Published 2010 Journal Acta Histochem. Section Title Doc Link 19056106 Disease Relevance 0 Pain Relevance 0.62
We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).
Regulation (involved) of Phosphorylation (phosphorylation) of NR1 in neurons associated with qutenza and dorsal horn neuron
16) Confidence 0.23 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312791 Disease Relevance 0 Pain Relevance 0.65
In addition, IT injection of the alpha-2 adrenoceptor antagonist, idazoxan (40 microg/rat) 10 min before clonidine injection completely reversed clonidine's antihyperalgesic and antiallodynic effects, as well as clonidine's suppressive effect on CCI-induced NR1 phosphorylation in the spinal cord dorsal horn.
Regulation (effect) of Phosphorylation (phosphorylation) of NR1 in spinal cord dorsal horn
17) Confidence 0.23 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18633054 Disease Relevance 0.05 Pain Relevance 0
Tissue injury induces NMDA receptor activation involving phosphorylation of the NR1 and NR2 subunits in the spinal dorsal horn [18,25,26].
Regulation (involving) of Phosphorylation (phosphorylation) of NR1 in dorsal horn associated with spinal dorsal horn, nmda receptor and injury
18) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.39 Pain Relevance 0.33
Immunohistochemistry was performed to determine potential SCI-induced changes in spinal astrocyte activation and phosphorylation of the NMDA receptor NR1 subunit (pNR1).
Regulation (changes) of Phosphorylation (phosphorylation) of NMDA receptor NR1 subunit in astrocyte associated with nmda receptor and frailty
19) Confidence 0.13 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20226782 Disease Relevance 1.59 Pain Relevance 1.31
These results demonstrate the distinct expression of phospho-NR1 subunits in different populations of striatal projection neurons and interneurons at variable levels in normal rats; they also demonstrate that phosphorylation of NR1, at least on serine 896 and 890 sites, is sensitive to drug exposure.
Regulation (sensitive) of in projection neurons Phosphorylation (phosphorylation) of NR1 in interneurons associated with projection neuron
20) Confidence 0.09 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15174082 Disease Relevance 0 Pain Relevance 0.52

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