INT119099

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Pkn1) signal transduction (Pkn1) histone binding (Pkn1)
cytoplasmic membrane-bounded vesicle (Pkn1) plasma membrane (Pkn1) nucleus (Pkn1)
Anatomy Link Frequency
neural 1
Pkn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 9 91.52 High High
nMDA receptor 33 85.76 High High
Thermal hyperalgesia 6 85.60 High High
intrathecal 6 75.00 Quite High
agonist 1 67.36 Quite High
Inflammation 29 62.64 Quite High
Visceral pain 8 58.24 Quite High
Glutamate 1 42.48 Quite Low
nud 10 33.20 Quite Low
Hyperalgesia 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 12 85.60 High High
INFLAMMATION 29 62.64 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

8 58.24 Quite High
Colitis 23 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 34.88 Quite Low
Dyspepsia 10 33.20 Quite Low
Injury 8 22.28 Low Low
Nociception 12 5.00 Very Low Very Low Very Low
Hypersensitivity 7 5.00 Very Low Very Low Very Low
Edema 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presence of the N1 insert reduced the apparent affinity of homomeric NR1 receptors for NMDA and almost abolished potentiation by spermine at saturating glycine [45], while splicing-in the N1 insert increased current amplitude [36,41].
Positive_regulation (increased) of N1
1) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.06 Pain Relevance 0.13
Activation of protease-activated receptors (PARs) in non-neural tissue results in prostaglandin production.
Positive_regulation (Activation) of protease-activated in neural
2) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15175421 Disease Relevance 0.23 Pain Relevance 0.45

General Comments

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