INT119100

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1, Ptgs1) nuclear envelope (Ptgs1) aging (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1)
Anatomy Link Frequency
spinal 3
F2rl1 (Rattus norvegicus)
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 2 98.88 Very High Very High Very High
Thermal hyperalgesia 6 98.44 Very High Very High Very High
Hyperalgesia 2 88.72 High High
intrathecal 6 79.04 Quite High
Glutamate 1 65.60 Quite High
Spinal cord 3 56.00 Quite High
agonist 1 53.12 Quite High
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 8 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that activation of spinal PAR 2 and possibly PAR 1 results in the stimulation of the spinal cyclooxygenase cascade and a prostaglandin-dependent thermal hyperalgesia.
Spec (1781) Positive_regulation (activation) of spinal PAR 2 in spinal Spec (possibly) Positive_regulation (results) of Spec (possibly) Positive_regulation (stimulation) of cyclooxygenase in spinal associated with thermal hyperalgesia
1) Confidence 0.03 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15175421 Disease Relevance 0.56 Pain Relevance 0.90

General Comments

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