INT119103

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.95
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (FIP1L1) nucleolus (FIP1L1) RNA binding (FIP1L1)
nucleus (FIP1L1)
Anatomy Link Frequency
eosinophils 1
hematopoietic cells 1
FIP1L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 75.40 Quite High
fibrosis 5 73.44 Quite High
corticosteroid 26 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypereosinophilic Syndrome 134 98.06 Very High Very High Very High
Leukemia 5 86.04 High High
Myeloproliferative Disorder 9 82.12 Quite High
Disease 72 76.48 Quite High
Splenomegaly 6 75.20 Quite High
Anaemia 5 74.64 Quite High
Thrombocytopenia 5 74.08 Quite High
Endomyocardial Fibrosis 4 73.44 Quite High
Hyperplasia 1 70.64 Quite High
Myelofibrosis 1 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following terms are currently used in medical literature to qualify different patient subsets among those fulfilling the diagnostic criteria of HES:

• FIP1L1-PDGFRA(F/P)-associated HES, or F/P+ HES, for patients with clonal hypereosinophilia due to a sporadic hematopoiëtic stem cell chromosomal rearrangement resulting in fusion of two genes (FIP1L1 and PDGFRA) on 4q12; these patients are more appropriately classified as F/P+ chronic eosinophilic leukemia. • Chronic eosinophilic leukemia (CEL), for patients in whom clonality of eosinophils has been demonstrated (including those with the FIP1L1-PDGFRA fusion), or who present increased blasts; occasional reports indicate that some patients with CEL progress towards acute myeloid or eosinophilic leukemia. • Lymphocytic-HES (L-HES), for patients with chronic reactive (polyclonal) hypereosinophilia secondary to IL-5 over-production by T cells. • Myeloproliferative-HES (M-HES) may be used for patients with an array of clinical and biological features suggesting the possible existence of an underlying myeloproliferative disorder associated with hypereosinophilia, although underlying molecular defects are not detected (including increased serum vitamin B12, hepato- and/or splenomegaly, anemia and/or thrombocytopenia, circulating myeloid precursors, dysplastic eosinophils, bone marrow hypercellularity with left shift in maturation, myelofibrosis, increased serum tryptase, and response to imatinib); this term is occasionally extended more largely to include patients with known molecular defects (e.g.

Gene_expression (fusion) of FIP1L1 in eosinophils associated with myeloproliferative disorder, anaemia, splenomegaly, hypereosinophilic syndrome, thrombocytopenia, myelofibrosis and hyperplasia
1) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2045078 Disease Relevance 1.94 Pain Relevance 0
The product of this fusion gene, FIP1L1-PDGFRalpha, is a constitutively active protein-tyrosine kinase capable of transforming hematopoietic cells.
Gene_expression (product) of FIP1L1 in hematopoietic cells
2) Confidence 0.44 Published 2004 Journal Semin. Oncol. Section Abstract Doc Link 15175999 Disease Relevance 1.01 Pain Relevance 0.11

General Comments

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