INT119108

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTBR, TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
LTBR (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 100.00 Very High Very High Very High
Etanercept 120 98.68 Very High Very High Very High
spinal inflammation 1 96.88 Very High Very High Very High
Arthritis 18 95.76 Very High Very High Very High
rheumatoid arthritis 46 94.92 High High
psoriasis 9 84.80 Quite High
cytokine 1 84.16 Quite High
antagonist 3 83.68 Quite High
methotrexate 45 49.12 Quite Low
metalloproteinase 1 5.28 Low Low
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
INFLAMMATION 2 100.00 Very High Very High Very High
Low Back Pain 1 96.88 Very High Very High Very High
Seronegative Spondarthritis 12 95.76 Very High Very High Very High
Rheumatoid Arthritis 49 94.92 High High
Psoriasis 9 84.80 Quite High
Disease 14 46.24 Quite Low
Arthritis 3 42.96 Quite Low
Adhesions 2 17.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etanercept is a human fusion protein of the tumor necrosis factor receptor (TNFR) and the Fc region of IgG1 that binds to and presumably inhibits the pro-inflammatory and pro-proliferative activity of the tumor necrosis factor (TNF).
TNFR Binding (activity) of TNF associated with necrosis, inflammation, cancer and etanercept
1) Confidence 0.15 Published 2004 Journal J Drugs Dermatol Section Abstract Doc Link 15176161 Disease Relevance 1.16 Pain Relevance 0.68
The biological activity of TNF is dependent upon binding to either cell surface TNFR.
TNFR Binding (binding) of TNF
2) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936291 Disease Relevance 0.31 Pain Relevance 0.39

General Comments

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