INT119124

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2A) enzyme binding (ADORA2A) cell-cell signaling (ADORA2A)
signal transducer activity (ADORA2A)
Anatomy Link Frequency
leukocytes 1
bladder 1
neutrophils 1
ADORA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 102 100.00 Very High Very High Very High
adenocard 37 100.00 Very High Very High Very High
Inflammation 70 99.16 Very High Very High Very High
antagonist 19 97.60 Very High Very High Very High
rheumatoid arthritis 3 89.16 High High
ischemia 3 86.28 High High
Inflammatory stimuli 1 77.36 Quite High
Inflammatory response 5 73.88 Quite High
chemokine 5 70.32 Quite High
cytokine 15 69.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 99.16 Very High Very High Very High
Rheumatoid Arthritis 3 89.16 High High
Pulmonary Disease 1 88.16 High High
Sepsis 1 86.60 High High
Cv Unclassified Under Development 3 86.28 High High
Infection 1 75.28 Quite High
Syndrome 1 67.36 Quite High
Bladder Disease 1 50.00 Quite Low
Injury 1 45.52 Quite Low
Adhesions 4 19.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synergistic effect of adenosine A2A receptors agonist, type IV phosphodiestease inhibitor and ATP-sensitive K channels activation on free radicals production and aggregation of human polymorphoneuclear leukocytes.
Positive_regulation (activation) of adenosine A2A in leukocytes associated with adenocard and agonist
1) Confidence 0.35 Published 2004 Journal Pharmacol. Res. Section Title Doc Link 15177304 Disease Relevance 0 Pain Relevance 0.35
A significant increase in suburothelial myofibroblast-like muscarinic receptor subtype 2 immunoreactivity was seen in patients with painful bladder syndrome (p = 0.0062) and idiopathic detrusor overactivity (p = 0.0002), and in muscarinic receptor subtype 3 immunoreactivity in those with idiopathic detrusor overactivity (p = 0.0122) with a trend in painful bladder syndrome.
Positive_regulation (increase) of muscarinic receptor subtype 2 in bladder
2) Confidence 0.27 Published 2006 Journal J. Urol. Section Body Doc Link 16753445 Disease Relevance 0.07 Pain Relevance 0
Adenosine, through activation of the A2A receptor (A2AR) subtype, ranks among the most potent agents limiting the inflammatory activities of neutrophils.
Positive_regulation (activation) of A2A receptor in neutrophils associated with adenocard and inflammation
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.89 Pain Relevance 0.51
Adenosine receptors (ARs) are G protein-coupled receptors, consisting of A1, A2A, A2B and A3 subtypes, activated by the endogenous agonist adenosine and blocked by natural antagonists, such as caffeine and theophylline.
Positive_regulation (activated) of A2A associated with adenocard, antagonist and agonist
4) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.29

General Comments

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