INT119132

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 2.66
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
dendrites 2
spines 1
spinal cord 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 17 100.00 Very High Very High Very High
Eae 60 99.96 Very High Very High Very High
antagonist 38 99.96 Very High Very High Very High
Dorsal horn 2 99.68 Very High Very High Very High
Glutamate 7 99.44 Very High Very High Very High
Morphine 30 99.02 Very High Very High Very High
Spinal cord 4 98.68 Very High Very High Very High
tolerance 11 97.76 Very High Very High Very High
Intracerebroventricular 1 97.00 Very High Very High Very High
Neuropeptide 1 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 94.60 High High
Targeted Disruption 155 94.28 High High
Syndrome 96 89.28 High High
Cognitive Disorder 17 85.00 Quite High
Anxiety Disorder 82 79.20 Quite High
Body Weight 10 72.68 Quite High
Morphine Dependence 1 69.20 Quite High
Alcohol Addiction 4 55.92 Quite High
Congenital Anomalies 8 54.08 Quite High
Intellectual Impairment 4 51.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if altered mGluR5 expression levels also affected locomotor activity relevant to OSS, we tested locomotor activity in a novel environment and after habituation.
Spec (determine) Regulation (altered) of mGluR5 associated with eae
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.12 Pain Relevance 0.41
To determine if altered mGluR5 expression levels also affected locomotor activity relevant to OSS, we tested locomotor activity in a novel environment and after habituation.
Spec (determine) Regulation (affected) of mGluR5 associated with eae
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.12 Pain Relevance 0.42
Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice.
Regulation (effects) of mGluR5 associated with antagonist, withdrawal and morphine
3) Confidence 0.44 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17222405 Disease Relevance 0.07 Pain Relevance 1.05
These data indicate that there was a significant influence of mGluR5 genotype on operant learning with OSS reinforcement on an FR-1 schedule of reinforcement, where heterozygous mice had enhanced responding and knockout mice had attenuated responding.
Regulation (influence) of mGluR5 associated with targeted disruption
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.22 Pain Relevance 0
A separate quantitative PCR analysis of genes in the last of these groups confirms the dysregulation of both orphan (Gpr88) and known (DrD1A, Adora2A, Cnr1, Grm5, Gpr6) G protein-coupled receptors, scaffolding (PSD95, Homer1) and signaling (Sgk, Cap1) proteins, and neuropeptides (CCK, galanin).
Regulation (dysregulation) of Grm5 associated with neuropeptide
5) Confidence 0.22 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18588537 Disease Relevance 0.18 Pain Relevance 0.74
Furthermore, repeated treatment with morphine produced a significant increase in the level of mGluR5 immunoreactivity in the dorsal horn of the mouse spinal cord.
Regulation (immunoreactivity) of mGluR5 in spinal cord associated with dorsal horn, spinal cord and morphine
6) Confidence 0.21 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.48
In conclusion, we found that OSS was highly susceptible to changes in mGluR5, as both the Hets and KOs had altered responding.
Regulation (changes) of mGluR5
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.52 Pain Relevance 0.09
As expected, mGluR5 immunoreactivity was in small dendritic spines.
Regulation (immunoreactivity) of mGluR5 in spines
8) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.10
It has been hypothesized that the absence of FMRP disrupts regulation of group 1 metabotropic glutamate receptor (mGluR and mGluR5)-dependent translation in dendrites [10].
Regulation (regulation) of mGluR5 in dendrites associated with glutamate receptor
9) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 0.72 Pain Relevance 0.05
It has been hypothesized that the absence of FMRP disrupts regulation of group 1 metabotropic glutamate receptor (mGluR and mGluR5)-dependent translation in dendrites [10].
Regulation (regulation) of mGluR in dendrites associated with glutamate receptor
10) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 0.71 Pain Relevance 0.05
Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice.
Regulation (Effects) of mGlu5 associated with glutamate, antagonist, tolerance and morphine
11) Confidence 0.00 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15178357 Disease Relevance 0 Pain Relevance 1.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox