INT119168

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.91
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd34) extracellular region (Cd34) cell motility (Cd34)
cell adhesion (Cd34) plasma membrane (Cd34) transcription factor binding (Cd34)
Anatomy Link Frequency
spindle cells 1
plasma 1
precursor cell 1
smooth muscle 1
Cd34 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 99.78 Very High Very High Very High
Inflammation 2 92.36 High High
dexamethasone 40 91.44 High High
Pain 3 86.40 High High
nud 1 86.04 High High
headache 3 80.32 Quite High
pain flank 1 75.72 Quite High
spastic colon 1 71.40 Quite High
imagery 6 61.04 Quite High
Central nervous system 5 58.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 34 99.88 Very High Very High Very High
Hyperplasia 1 99.38 Very High Very High Very High
Hypersensitivity 3 98.00 Very High Very High Very High
Neurilemmoma 7 97.64 Very High Very High Very High
Brain Tumor 3 95.68 Very High Very High Very High
Malignant Neoplastic Disease 2 92.80 High High
INFLAMMATION 2 92.36 High High
Solitary Fibrous Tumors 3 91.40 High High
Recurrence 8 90.64 High High
Meningioma 2 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Review of the original tumour also disclosed immunoreactivity for CD34.
Negative_regulation (disclosed) of CD34 associated with cancer
1) Confidence 0.37 Published 2005 Journal J Clin Neurosci Section Abstract Doc Link 16169731 Disease Relevance 1.55 Pain Relevance 0.14
Three days after the last injection, the number of CD34+/CD45?
Negative_regulation (number) of CD34
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0 Pain Relevance 0
The expression of surface markers CD34 (Santa Cruz, USA) and CD45 (Cedarlane Laboratories, Canada) were measured in a LSR II flow cytometer (Becton Dickinson, USA) using the Cell Quest software (Becton Dickinson, USA).
Negative_regulation (measured) of CD34
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0 Pain Relevance 0
Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects.
Negative_regulation (reduce) of CD34 in precursor cell associated with hypersensitivity and cytokine
4) Confidence 0.28 Published 2004 Journal Eur Ann Allergy Clin Immunol Section Title Doc Link 15180351 Disease Relevance 0.80 Pain Relevance 0.21
RESULTS: A synergistic interaction (P = 0.015) between decreased CD34+/KDR+ cell counts and increased plasma ADMA, but not symmetrical dimethyl-L-arginine, was the sole significant multivariate DeltaeGFR predictor irrespective of baseline eGFR.
Negative_regulation (decreased) of CD34 in plasma
5) Confidence 0.14 Published 2010 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19729464 Disease Relevance 0.14 Pain Relevance 0
A combined use of immunostains (S-100 protein, EMA, CD34, and maybe calretinin) is of great help in distinguishing ICS from its histological mimickers.
Negative_regulation (use) of CD34 associated with neurilemmoma
6) Confidence 0.11 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15998381 Disease Relevance 0.74 Pain Relevance 0.03
Immunohistochemistry was positive for CD34, vimentin; and negative for GFAP (glial fibrillary acidic protein) and SMA (smooth muscle actin).
Negative_regulation (positive) of CD34 in smooth muscle
7) Confidence 0.09 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1654154 Disease Relevance 0.95 Pain Relevance 0.16
A retrospective study addressed specifically this issue; the total number of CD34 cells collected was not affected by previous duration or dose of thalidomide, or duration between thalidomide cessation and mobilization (Ghobrial et al 2003), while in another study the median number of CD34 was affected by the time from thalidomide discontinuation (Abdelkefi et al 2005).
Negative_regulation (number) of CD34
8) Confidence 0.07 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374936 Disease Relevance 0.07 Pain Relevance 0.34
Pathological examination revealed hypercellularity of spindle cells, that showed positive for CD34, vimentin, desmin and Mic-2, and negative for S100, alphaSMA, c-kit, AE1/3, p53 and bcl-2.
Negative_regulation (positive) of CD34 in spindle cells associated with hyperplasia
9) Confidence 0.07 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20610922 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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